Adsorption Behavior of Sodium Inositol Hexaphosphate on the Surface of Hydroxyapatite

Abstract:

We have previously developed hydroxyapatite (HAp) cement based on the chelate-setting mechanism of sodium inositol hexaphosphate (IP6), in which HAp powder was prepared by surface-modification with IP6 after ball-milling of the HAp powder (conventional process). Meanwhile, we have recently established novel powder preparation process (modified process). In the present study, the adsorption behavior of IP6 on the surface of HAp at both the processes was circumstantially examined to clarify the chelating mechanism of IP6. The adsorbed amount of IP6 increased with the IP6 concentration in both the processes; however, the adsorbed amount of IP6 at the modified process was lower than that at the conventional process. X-ray photoelectron spectroscopic study revealed that the IP6 adsorbed on the surface of HAp powders. The degree in dispersion of the HAp particles at the modified process was higher than that at conventional process. Furthermore, the elution of IP6 from the powders prepared at the novel process was lower than that of the powders at the conventional process.

• Periodical: Key Engineering Materials (Volumes 529-530)
• Pages: 161-166
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.529-530.161
• Online since: November 2012
• Authors: Toshiisa Konishi, Minori Mizumoto, Michiyo Honda, Mamoru Aizawa
• Keywords: Bone Graft, Calcium Phosphate Cement, Inositol Hexaphosphate, Surface Modification

References

[1] W. E. Brown, L. C. Chow, U.S. Patent, 4, 518, 430. (1985).

[2] Y. Miyamoto, K. Ishikawa, M. Takechi, T. Toh, T. Yuasa, M. Nagayama, K. Suzuki, Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing, J. Biomed. Mater. Res. 48 (1999).

DOI: 10.1002/(sici)1097-4636(1999)48:1<36::aid-jbm8>3.0.co;2-i

[3] M. Aizawa, Y. Haruta, I. Okada, Development of novel cement processing using hydroxyapatite particles modified with inositol phosphate, Arch. BioCeram. Res. 3 (2003) 134–138.

[4] Y. Horiguchi, Y. Yoshikawa, K. Oribe, M. Aizawa, Fabrication of chelate-setting hydroxyapatite cements from four kinds of commercially-available powder with various shape and crystallinity and their mechanical property, J. Ceram. Soc. Jpn. 116 (2008).

DOI: 10.2109/jcersj2.116.50

[5] T.H. Dao, Polyvalent cation effects on myo-inositol hexakis dihydrogenphosphate enzymatic dephosphorylation in dairy wastewater, J. Environ. Qual. 32 (2003) 694–701.

DOI: 10.2134/jeq2003.6940

[6] C.J. Martin, W.J. Evans, Phytic acid-metal ion interactions. II. The effect of pH on Ca(II) binding, J. Inorg. Biochem. 27 (1986) 17–30.

DOI: 10.1016/0162-0134(86)80105-2

[7] T. Konishi, Z. Zhuang, M. Mizumoto, M. Honda, M. Aizawa, Fabrication of chelate-setting cement from hydroxyapatite powder prepared by simultaneously grinding and surface-modifying with sodium inositol hexaphosphate and their material properties, J. Ceram. Soc. Jpn. 120 (2012).

DOI: 10.2109/jcersj2.120.159

[8] NIST X-ray Photoelectron Spectroscopy Database, Version 3. 5, National Institute of Standards and Technology, Gaithersburg, 2003. Information on http: /srdata. nist. gov/xps.

[9] H.W. Kaufman, Interactions of inositol phosphate with mineralized tissues, in: E. Graf (ed. ), Phytic acid: chemistry and applications, Pilatus Press, Minneapolis, 1986, p.303–320.

[10] H. Yang, Y. Yang, Y. Yang, H. Liu, Z. Zhang, G. Shen, R. Yu, Formation of inositol hexaphosphate monolayers at the copper surface from a Na-salt of phytic acid solution studied by in situ surface enhanced Raman scattering spectroscopy, Raman mapping and polarization measurement, Anal. Chim. Acta. 548 (2005).

DOI: 10.1016/j.aca.2005.05.061