A PDMS Micropump for Implantable Drug Delivery Application

Abstract:

This paper presents an integrated magnetic PDMS micropump for implantable drug delivery application. The micropump mainly consists of two structural PDMS layers: a PDMS functional layer that incorporates microchannels, a pump chamber and two planar check valves into a single layer, allowing for simple design and easy system integration, and the other PDMS membrane layer covering the pump chamber and holding a thin electroplated permalloy piece on top for magnetic actuation. The micropump can be driven by the interaction between the ferromagnetic permalloy and an external electromagnet, providing a remote and wireless operation method. Test results demonstrate that this micropump is able to produce a maximal flow rate of 0.15 μL/min at the driving frequency of 2 Hz with a volume resolution of approximately 1 nL per stroke, promising its application in various implantable biomedical systems.

• Periodical: Key Engineering Materials (Volumes 562-565)
• Pages: 680-685
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.562-565.680
• Online since: July 2013
• Authors: Jun Hui Ni, Bai Shao Zhan, Jun Li
• Keywords: Drug Delivery, Magnetic, Micropump, PDMS

References

[1] Shawgo R S, Grayson A C R, Li Y, et al. BioMEMS for drugdelivery, Current Opinion in Solid State and Materials Science. 6 (2002) 329-334.

DOI: 10.1016/s1359-0286(02)00032-3

[2] Yang Y-N, Hsiung S-K, and Lee G-B, A pneumatic micropump incorporated with a normally closed valve capable of generating a high pumping rate and a high back pressure, Microfluidics and Nanofluidics. 6 (2009) 823-833.

DOI: 10.1007/s10404-008-0356-7

[3] Huang S-B, Wu M-H, Cui Z-F, et al, A membrane-based serpentine-shape pneumatic micropump with pumping performance modulated by fluidic resistance, J. Micromech. Microeng. 18 (2008) 1-22.

DOI: 10.1088/0960-1317/18/4/045008

[4] Bertarelli E, Corigliano A, Greiner A, et al. Design of high stroke electrostatic micropumps: a charge control approach with ring electrodes, Microsystem Technologies. 17 (2011) 165-173.

DOI: 10.1007/s00542-010-1185-7

[5] Zengerle R, Ulrich J, Kluge S, et al. A bidirectional silicon rnicropump, Sensors and Actuators A. 50 (1995) 81-86.

DOI: 10.1016/0924-4247(96)80088-4

[6] Guan Y-F, Zhang G-X, and Yu Z-Y, Fabrication and experiments of piezoelectric micropump with novel saw tooth microchannels, Nanotechnology and Precision Engineering. 8 (2010) 149-155.

[7] Jang L-S and Yu Y-C, Peristaltic micropump system with piezoelectric actuators, Microsyst. Technol. 14 (2008) 241-248.

DOI: 10.1007/s00542-007-0428-8

[8] Ha S-M, Cho W, and Ahn Y, Disposable thermo-pneumatic micropump for bio lab-on-a-chip application, Microelectronic Engineering, 86 (2009) 1337-1339.

DOI: 10.1016/j.mee.2008.12.046

[9] Kurtoglu E, Bilgin A, Sesen M, et al. Ferrofluid actuation with varying magnetic fields for micropumping applications, Microfluid Nanofluid. 13 (2012) 683-694.

DOI: 10.1007/s10404-012-1008-5

[10] Lee S-M, Kuan Y-D, and Sung M-F, Design and fabrication of a magnetic fluid micropump for applications in direct methanol fuel cell, Journal of Power Sources. 196 (2011) 7609-7615.

DOI: 10.1016/j.jpowsour.2011.04.060

[11] Chang H-T, Wen C-Y, and Lee C-Y, Design, analysis and optimization of an electromagnetic actuator for a microimpedance pump, J. Micromech. Microeng. 19 (2009) 1-12.

[12] Yang B and Lin Q, Planar micro-check valves exploiting large polymer compliance, Sensors and Actuators A. 134 (2007) 186-193.

DOI: 10.1016/j.sna.2006.07.016

[13] Judy J W and Muller R S, Magnetic Microactuation of Polysilicon Flexure Structures, Journal of microelectromechanical systems. 4 (1995) 162-169.

DOI: 10.1109/84.475542

[14] Khoo M and Liu C, Micro magnetic silicone elastomer membrane actuator, Sensors and Actuators A. 89 (2001) 259-266.

DOI: 10.1016/s0924-4247(00)00559-8

[15] Jo B-H, Lerberghe L M V, Motsegood K M, et al. Three-Dimensional Micro-Channel Fabrication in Polydimethylsiloxane (PDMS) Elastomer, Journal of microelectromechanical systems. 9 (2000) 76-81.

DOI: 10.1109/84.825780

[16] Ni J, Huang F, Wang B, et al. A planar PDMS micropump using in-contact minimized-leakage check valves, Journal of Micromechanics and Microengineering. 20 (2010) 1-7.

DOI: 10.1088/0960-1317/20/9/095033