Electrochemical Measurements of Phenothiazine Drugs in the Presence of Surface Active Ionic Liquids

Reshu Talwar; Rakesh Kumar Mahajan

doi:10.4028/www.scientific.net/KEM.605.581

Paper Titles

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Different Chemical Approaches for the Synthesis of Polyaniline Nanofibers and its Application in Ammonia Gas Sensing
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Hydrogen-Terminated Diamond Sensors for Electrical Monitoring of Cells
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Electrochemical Measurements of Phenothiazine Drugs in the Presence of Surface Active Ionic Liquids
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Synthesis of ZnO Nanorod Arrays by Chemical Solution and Microwave Method for Sensor Application
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Fabrication of Diamond Based Quartz Crystal Microbalance Gas Sensor
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Morphology and Laser-Induced Photochemistry of Silicon and Nickel Nanoparticles
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Tuning the Molecular Sensitivity of Conductive Polymer Resistive Sensors by Chemical Functionalization
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Electrochemical Measurements of Phenothiazine Drugs in the Presence of Surface Active Ionic Liquids

Abstract:

The present study aims to explore the interactions between phenothiazine drugs (viz. promethazine hydrochloride (PMT) and promazine hydrochloride (PMZ)) and 1-alkyl-3-butylimidazolium based surface active ionic liquids (SAILs) using conductivity, cyclic voltammetry and DPV measurements. The drugs have been found to form mixed micelles with the SAILs and thus vary the micellar parameters of SAILs as evaluated from conductivity measurements,. Moreover, phenothiazine drugs are known to exhibit redox behavior which is prone to change in the presence of SAILs. This change in the redox active behavior is seen to be dependent on the concentration as well as the nature of the alkyl chain of both drugs and SAILs. The interactions between the drugs and the SAILs have been found to be electrostatic as well as hydrophobic.