Injectable Bioactive Glass/Polysaccharide Polymers Nanocomposites for Bone Substitution

Mehri Sohrabi; Saeed  Hesaraki; Asghar Kazemzadeh

doi:10.4028/www.scientific.net/KEM.614.41

Paper Titles

Biomimetic Apatite Deposition within Casein-Loaded Hydrogel Scaffolds
p.22

Comparison between the Microstructure of the Mineral Phase in Two Types of Composite Beads for Bone Regeneration
p.26

Effect of Silicon-Doped Calcium Phosphate Bone Substitutes on Bone Formation and Osteoblastic Phenotype Expression In Vivo
p.31

Influence of Time on Thermal Oxidation of CP-Ti Grade II at 850 °C
p.35

Injectable Bioactive Glass/Polysaccharide Polymers Nanocomposites for Bone Substitution
p.41

SEM Characterisation of a Tricalcium Phosphate – Chitosan - PMMA Cement
p.47

Synthesis of Calcium Carbonate Biological Materials: How Many Proteins are Needed?
p.52

The Effect of α-Tricalcium Phosphate Powder Preparation Methods on Cement Properties
p.62

Structural and Surface Characterization of some Ceramic Coatings Obtained by Plasma Jet Spraying on Metallic Biomaterials Substrates
p.68

HomeKey Engineering MaterialsKey Engineering Materials Vol. 614Injectable Bioactive Glass/Polysaccharide Polymers...

Injectable Bioactive Glass/Polysaccharide Polymers Nanocomposites for Bone Substitution

Abstract:

nanobioactive glasses are biocompatible and osteoconductive materials which can be mixed with solution of biocompatible polymers to make nanobiocomposite paste for hard and even soft tissue treatment. In this study, bioactive glass based on CaO-SiO₂-P₂O₅ system was produced via sol-gel technique and mixed with a solution phase. The solution phase was a 1:1 mixture of 3% hyaluronic acid solution and 3% sodium alginate solution in v/v. Rheological behaviors of the paste in rotation and oscillation modes were measured. For surface reactivity measurements, the paste was immersed in simulated body fluid (SBF) for different intervals and then characterized by SEM. The paste exhibited a superior injectability even from syringes with too narrow tips. It was a thixotropic fluid with shear thinning behavior. The results of surface reactivity revealed precipitation of apatite phase on the paste surfaces meanwhile an appropriate structural stability was observed against disintegration (anti-washout behavior). It seems that this biocomposite paste is an appropriate alternative for injectable bone substitute materials.

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Key Engineering Materials (Volume 614)

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41-46

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https://doi.org/10.4028/www.scientific.net/KEM.614.41

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Online since:

June 2014

Authors:

Mehri Sohrabi*, Saeed Hesaraki, Asghar Kazemzadeh

Keywords:

Bioactive Glass, Injectability, Nanocomposite, Rheology

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