Fe3O4@TiO2 Nanocomposites for Magnetic Targeting Sonodynamic Therapy of Cancer

Song Shen; Bei Ding; Lin Wu; Xue Yong Qi; Yan Ru Ge

doi:10.4028/www.scientific.net/KEM.636.129

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 636Fe3O4@TiO2 Nanocomposites for Magnetic Targeting...

Fe₃O₄@TiO₂ Nanocomposites for Magnetic Targeting Sonodynamic Therapy of Cancer

Abstract:

Uniform Fe₃O₄@TiO₂ nanocomposites were successfully synthesized via a sol-gel method and then characterized by transmission electron microscope (TEM) and X-ray diffraction (XRD). The obtained composites were monodispersed spherical nanoparticles with average diameter of ~ 230 nm. In vitro cytotoxicity experiment, Fe₃O₄@TiO₂ nanocomposites exhibited good biocompatibility and obvious sonodynamic therapy (SDT) effect. Over 50% cells were killed when the cells were treated with Fe₃O₄@TiO₂ and ultrasound for 1 min. The results indicated the potential of Fe₃O₄@TiO₂ for targeted sonodynamic therapy of tumor.

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Periodical:

Key Engineering Materials (Volume 636)

Pages:

129-132

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.636.129

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Online since:

December 2014

Authors:

Song Shen, Bei Ding, Lin Wu, Xue Yong Qi, Yan Ru Ge*

Keywords:

Core-Shell, Magnetic Iron Oxide, Sonodynamic Therapy, Tumor Targeting

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* - Corresponding Author

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