A Novel Chitosan Microbubble as Ultrasound-Triggered Drug Carrier for Antitumor In Vitro

Song Shen; Bei Ding; Qing Li; Xu Wei Yu; Xue Yong Qi; Yan Ru Ge

doi:10.4028/www.scientific.net/KEM.636.139

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 636A Novel Chitosan Microbubble as...

A Novel Chitosan Microbubble as Ultrasound-Triggered Drug Carrier for Antitumor In Vitro

Abstract:

Uniform Microbubbles (MBs) were routinely used as ultrasound contrast agents, but the MBs served for drug carrier showed well-marked advantage. In this study, we prepared a novel docetaxel–loaded microbubbles by carboxymethyl chitosan with W/O/W emulsion technique. Then, the surface morphology was characterized by scanning electron microscope (SEM). Ultrasound-triggered drug release experiments were performed with adjustable intensity and time. In the antitumor experiment in vitro, Ultrasound-assisted drug release from MBs exhibited good treatment of tumor. The results proved the combination of ultrasound and drug-loaded carboxymethyl chitosan microbubbles could be used as a potential strategy for anti-tumor therapy.

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Periodical:

Key Engineering Materials (Volume 636)

Pages:

139-143

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.636.139

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Online since:

December 2014

Authors:

Song Shen, Bei Ding, Qing Li, Xu Wei Yu, Xue Yong Qi, Yan Ru Ge*

Keywords:

Antitumor, Chitosan Microbubble, Drug Carrier, Ultrasound

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References

[1] X.J. Kang, Y. L Dai, P. A Ma, Poly(acrylic acid)-Modified Fe3O4 microspheres for magnetic-targeted and pH-triggered anticancer drug delivery, Chemistry-A European Journal, 18(2012) 15676–15682.

DOI: 10.1002/chem.201202433

Google Scholar

[2] Y.N. Zhong, C. Wang, L. Cheng, F.H. Meng, Z.Y. Zhong, Z. Liu, Gold nanorod-cored biodegradable micelles as a Robust and remotely controllable doxorubicin release system for potent inhibition of drug-sensitive and -resistant cancer cells, Biomacromolecules, 14(2013).

DOI: 10.1021/bm400530d

Google Scholar

[3] S.R. Sirsia, M.A. Borden, State-of-the-art materials for ultrasound-triggered drug delivery, Advanced Drug Delivery Reviews, 72(2014) 3-14.

DOI: 10.1016/j.addr.2013.12.010

Google Scholar

[4] S. Fokong, B. Theek, Z.J. Wu, P. Koczera, L. Appold, Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles, Journal of Controlled Release, 163 (2012) 75-81.

DOI: 10.1016/j.jconrel.2012.05.007

Google Scholar

[5] R.R. Suna, M.L. Noblea, S.S. Suna, S.X. Song, C.H. Miao, Development of therapeutic microbubbles for enhancing ultrasound-mediated gene delivery, Journal of Controlled Release, 182(2014) 111-120.

DOI: 10.1016/j.jconrel.2014.03.002

Google Scholar