Optimization of Chitosan-Based Scaffolds Obtained via Cathodic Polarization

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Abstract:

Cathodic polarization is a powerful technique largely used for the deposition of thin films on metallic substrates; it offers the distinctive advantage of an easy control over the composition, thickness, and morphology of the films by simply adjusting the process parameters such as the electrolyte bath composition, the applied potential (or current density), and the process duration. In this work, electrochemical deposition (ECD) was exploited to engender biopolymer blends composed by chitosan/collagen and chitosan/poly (ethylene oxide) and deposited at different weight ratios (5:1, 3:1) and compared to pristine material. Our findings demonstrate that ECD is an effective technique for the preparation of scaffolds made of chitosan blends in which morphology and mechanical properties can be optimized via scaffold composition.

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154-158

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July 2015

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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[1] I. Y. Kim, S.J. Seo, H.S. Moon, M.K. Yoo, I.Y. Park, B.C. Kim, C.S. Cho, Chitosan and its derivatives for tissue engineering applications Biotechnol. Adv. 26 (2008) 1-21.

DOI: 10.1016/j.biotechadv.2007.07.009

Google Scholar

[2] A. Simchi, F. Pishbin, A.R. Boccaccini, Electrophoretic deposition of chitosan Mater. Lett. 63 (2009), 2553-2556.

Google Scholar

[3] L. Altomare, L. Draghi, R. Chiesa, L. De Nardo Morphology tuning of chitosan films via electrochemical deposition Mater. Lett. 78 (2012), 18–21.

DOI: 10.1016/j.matlet.2012.03.035

Google Scholar

[4] C Deng,. P. C Zhang,. B Vulesevic,. D. Kuraitis, F. F. Li, A. F Yang,. M. Griffith, M. Ruel, E. J. Suuronen, A Collagen-Chitosan Hydrogel for Endothelial Differentiation and Angiogenesis, Tissue Eng Part A 16 (2010) 3099-3109.

DOI: 10.1089/ten.tea.2009.0504

Google Scholar

[5] T. Zhang, L. Q. Wan, Z. Xiong, A. Marsano, R. Maidhof, M. Park, YNA. Yan, G. Vunjak-Novakovic, Channelled scaffolds for engineering myocardium with mechanical stimulation J Tissue Eng Regen Med. 6 (2012).

DOI: 10.1002/term.481

Google Scholar

[6] M. Araña, E. Peña, G. Abizanda, M. Cilla, I. Ochoa, J.J. Gavira, et al. Preparation and characterization of collagen-based ADSC-carrier sheets for cardiovascular application. Acta Biomaterialia, 9 (2013)., 6075-6083.

DOI: 10.1016/j.actbio.2012.12.014

Google Scholar

[7] S Zivanovic, J. Li, P. M. Davidson and K. Kit Physical, Mechanical, and Antibacterial Properties of Chitosan/ PEO blend films Biomacromolecules 8 (2007), 1505-1510.

DOI: 10.1021/bm061140p

Google Scholar

[8] M. Dilamiana, M. Montazerb, , J. Masoumic, Antimicrobial electrospun membranes of chitosan/poly(ethylene oxide), incorporating poly(hexamethylene biguanide), hydrochloride Carbohydr Polym 94 (2013) 364-371.

DOI: 10.1016/j.carbpol.2013.01.059

Google Scholar

[9] M. Pakravana, MC Heuzeya, A. Ajjia, A fundamental study of chitosan/PEO electrospinning Polymer 52 (2011) 4813-4814.

Google Scholar

[10] L. Altomare, E. Guglielmo, E. Varoni, S. Bertoldi, A. Cochis, L. Rimondini, L. De Nardo, Design of 2D chitosan scaffolds via electrochemical structuring, Biomatter, 4 (2014), e29506.

DOI: 10.4161/biom.29506

Google Scholar

[11] R. L. Mason, R. F. Gunst James, L. Hess Statistical Design and Analysis of Experiments With Applications to Engineering and Science, Wiley Interscience, Eds JOHN WILEY & SONS PUBLICATION, (2003).

Google Scholar

[12] M.N. Taravel and A. Domard Collagen and its interaction with chitosan: III. some biological and mechanical properties. Biomaterials 17 (1996) 451-455.

DOI: 10.1016/0142-9612(96)89663-3

Google Scholar