Influence of Mineral Salts on the Production of Antibiotics Phenazine Series from Pseudomonas Aeruginosa

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Phenazines represent a group of heterocyclic nitrogen-containing compounds showing a broad spectrum of antibiotic properties. Phenazines are studied extensively for their further application in plant disease management. Pseudomonas aeruginosa produce phenazine compounds as the secondary metabolites. In this paper a complex of phenazine series antibiotics from the culture of Pseudomonas aeruginosa was isolated and studied. It was established that the complex represented by phenazine-1-carboxylic acid and 2-hydroxyphenazine. The influence of various mineral salts to produce phenazine was investigated. Inhibitors and cofactors of the biosynthesis of antibiotics phenazine series were determined.

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794-797

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February 2016

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© 2016 Trans Tech Publications Ltd. All Rights Reserved

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[1] Y. Zhang, S. Nakkeeran, W. G. D. Fernando, Biosynthesis of antibiotics by PGPR and its relation in biocontrol of plant diseases, Biocontrol and Biofertilization. 3 (2005) 67– 109.

DOI: 10.1007/1-4020-4152-7_3

Google Scholar

[2] M. McDonald, D. Mavrodi, L. Thomashow, H. Floss, Phenazine biosynthesis in Pseudomonas fluorescens: Branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1, 6-dicarboxylic acid, J Am Chem Soc. 123 (2001) 9459–9460.

DOI: 10.1021/ja011243+

Google Scholar

[3] H. Liu, Y. He, H. Jiang, H. Peng, X. Huang, X. Zhang, L. S. Thomashow, and Y. Xu, Characterization of a phenazine producing strain Pseudomonas chlororaphis GP72 with broad spectrum antifungal activity from green pepper rhizosphere, Curr. Microbiol. 54 (2007).

DOI: 10.1007/s00284-006-0444-4

Google Scholar

[4] D. Hass, G. Defaro, Biological control of soil borne pathogens by fluorescent pseudomonas, Nature Reviews Microbiology. 1129 (2005) 87-91.

Google Scholar

[5] S. Saha, R. Thavasi, S. Jayalakhsmi, Phenazine pigments from Pseudomonas aeruginosa and their application as antibacterial agent and food colourants, Research Journal of Microbiology. 3 (2008) 122-128.

DOI: 10.3923/jm.2008.122.128

Google Scholar

[6] N. Aunchale, A. Sukanya, P. Chanokporn, P. Paweena, C. Saksit & R. Chalerm, Synthetic, isolation of phenazine derivatives and their antimicrobial activities. Walailak J. Sci. and Tech. 6(1) (2009) 78-91.

Google Scholar

[7] W. Blankenfeldt, J. F Parsons, The structural biology of phenazine biosynthesis, Current Opinion in Structural Biology. 29 (2014) 26–33.

DOI: 10.1016/j.sbi.2014.08.013

Google Scholar

[8] D. Mavrodi, W. Blankenfeldt, L. Thomashow, M. Mental, Phenazine compounds in fluorescent Pseudomonas spp. Biosynthesis and regulation, Annual review of Phytopathol. 44 (2006) 417-445.

DOI: 10.1146/annurev.phyto.44.013106.145710

Google Scholar

[9] J.M. Turner, A.J. Messenger, Occurrence, biochemistry and physiology of phenazine pigment production, Advan. in Microbi. Physiolo. 27 (1986) 211-275.

DOI: 10.1016/s0065-2911(08)60306-9

Google Scholar