Synthesis and Study of Norfloxacin Labeled with Technecium-99m as a Potential Imaging Agent of Bacterial Inflammations

Natalya V. Varlamova; Viktor S. Skuridin; Aleksey E. Sazonov; Svetlana I. Sazonova; Evgeniy A. Nesterov; Liudmila A. Larionova

doi:10.4028/www.scientific.net/KEM.685.798

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 685Synthesis and Study of Norfloxacin Labeled with...

Synthesis and Study of Norfloxacin Labeled with Technecium-99m as a Potential Imaging Agent of Bacterial Inflammations

Abstract:

Investigations have been carried out into creation of reagent for labeled norfloxacin hydrochloride (NFH).Methods: The NFH synthesized in the Institute of Organic Synthesis (Ekaterinburg) was used in this research. The effect of the mixture components on the radiochemical specimen purity was assessed using the method of thin-layer chromatography.Results: The inflammation animal model was used to demonstrate the NFH functional eligibility for diagnostics of inflammatory processes.

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Periodical:

Key Engineering Materials (Volume 685)

Pages:

798-802

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.685.798

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Online since:

February 2016

Authors:

Natalya V. Varlamova*, Viktor S. Skuridin, Aleksey E. Sazonov, Svetlana I. Sazonova, Evgeniy A. Nesterov, Liudmila A. Larionova

Keywords:

^99mТс’, Bacterial Infection, Norfloxacin Hydrochloride (NFH), Radionuclide Diagnostics, RP ‘Norfloxacin, Technecium-99m (^99mTc)

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