Preparation of β-CD-HAP Composite Microspheres

Article Preview

Abstract:

β-cyclodextin-hydroxyapatite (β-CD-HAP) composite microspheres were prepared in invert microemulsion method using spherical morphology hydroxyapatite nanoparticles (nHAP) as raw materials, Span-Tween cosurfactant as mixed emulsifier and epichlorohydrin as cross linker agent. The structure, morphology and β-CD-HAP was characterized by Fourier transform Infrared spectroscope (FT-IR), X-ray powder diffraction (XRD), transmission electron microscope (SEM). Results showed that the β-CD-HAP microspheres were synthesized by adding epichlorohydrin, span-80, tween-80, and sodium hydroxide and the particle size of β-CD-HAP composite microsphere with good dispersion was several tens of nanometer.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

67-70

Citation:

Online since:

July 2016

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2016 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] Y. J. Wang, X. D Wang, K. Wei, Surfctant-assisted synthesis of hydroxyapatite particles, Mater. Lett. 60 (2006) 3227–3231.

Google Scholar

[2] T. K. Chaki, P. E. Wang, DensiÞcation and strengthening of silverreinforced hydroxyapatitematrix composite prepared by sintering, J Mater Sci Mater Med. 5 (1994) 533-42.

Google Scholar

[3] S. Dasgupta, A. Bandyopadhyay, S. Bose, Reverse micelle-mediated synthesis of calcium phosphate nanocarriers for controlled release of bovine serum albumin, Acta Biomaterialia. 5 (2009) 3112–3121.

DOI: 10.1016/j.actbio.2009.04.031

Google Scholar

[4] T. Y. Liu, S. Y. Chen, D. M. Liu, On the study of BSA-loaded calcium-deficient hydroxyapatite nano-carriers for controlled drug delivery, J. Control. Release. 107 (2005) 112–121.

DOI: 10.1016/j.jconrel.2005.05.025

Google Scholar

[5] B. Palazzo, M. Iafisco, M. Laforgia, Biomimetic hydraxyapatite-drug nanocrystals as potential bone substitutes with antitumor drug delivery properties, Adv. Funct. Mater. 17 (2007) 2180-2188.

DOI: 10.1002/adfm.200600361

Google Scholar

[6] Y. Mizushima, T. Ikoma, J. Tanaka, Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs Ogawa, et al. J. Control. Release. 110 (2006) 110-260.

DOI: 10.1016/j.jconrel.2005.09.051

Google Scholar

[7] H. Liu, C. Liu, X. Yang, Uniformly sized β-cyclodextrin molecularly imprinted microspheres prepared by a novel surface imprinting technique for ursolic acid, Anal. Chim. Acta. 628 (2008) 87–94.

DOI: 10.1016/j.aca.2008.08.042

Google Scholar

[8] S. Bose, S. K. Saha, Synthesis and Characterization of Hydroxyapatite Nanopowders by Emulsion Technique, Chem. Mater. 15 (2003) 4464–4469.

DOI: 10.1021/cm0303437

Google Scholar