Preparation and Evaluation of Calcium Sulfate/Collagen Composite Pellets

Xu Zhao He; Jun Jun Zhuang; Kui Cheng; Wen Jian Weng

doi:10.4028/www.scientific.net/KEM.758.138

Paper Titles

Kinetics and the Theoretical Aspects of Drug Release from PLA/HAp Thin Films
p.113

Antibiotic Containing Poly Lactic Acid/Hydroxyapatite Biocomposite Coatings for Dental Implant Applications
p.120

Development of Controllable Simvastatin-Releasing PLGA/β-TCP Composite Microspheres Sintered Scaffolds as Synthetic Bone Substitutes
p.126

Strategies to Improve Bioactivity of Hydroxyapatite Bone Scaffolds
p.132

Preparation and Evaluation of Calcium Sulfate/Collagen Composite Pellets
p.138

Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering
p.145

Hydroxyapatite Bioceramics Reinforced with Silica-Coated Graphene
p.150

Conversion of Calcified Algae (Halimeda sp) and Hard Coral (Porites sp) to Hydroxyapatite
p.157

Development of Ultra-Thin Opaque White Hydroxyapatite Sheet for Restoration of Enamel and Aesthetic Treatments of Teeth
p.162

HomeKey Engineering MaterialsKey Engineering Materials Vol. 758Preparation and Evaluation of Calcium...

Preparation and Evaluation of Calcium Sulfate/Collagen Composite Pellets

Abstract:

Calcium sulfate/type I collagen composite pellets were prepared by a feasible route of casting method. The as-prepared composite pellets were characterized and the results showed that the collagen fibrils acted as bridges to connect the adjacent calcium sulfate grains, especially when there was a high mass loading of collagen, which effectively depressed the rapid degradation of the pellets and improved compressive strength, and the optimal strength reached 17.2 MPa with 6 mg/mL collagen solution. The MC3T3-E1 cells could be well attached and spread on the surface of the composite pellets. Moreover, it is found that the collagen be released through pellets degradation further promoted the cells proliferation.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volume 758)

Pages:

138-144

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.758.138

Citation:

Cite this paper

Online since:

November 2017

Authors:

Xu Zhao He, Jun Jun Zhuang, Kui Cheng*, Wen Jian Weng

Keywords:

Bone Repairing Material, Composite Pellets, Type I Collagen, α-Calcium Sulphate

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] Gitelis S, Piasecki P, Turner T, Haggard W, Charters J, Urban R. Use of a calcium sulfate-based bone graft substitute for benign bone lesions. Orthopedics. 2001; 24: 162-166.

DOI: 10.3928/0147-7447-20010201-19

Google Scholar

[2] Pietrzak WS, Ronk R. Calcium sulfate bone void filler: a review and a look ahead. Journal of Craniofacial Surgery. 2000; 11: 327-333.

DOI: 10.1097/00001665-200011040-00009

Google Scholar

[3] Alderman NE. Sterile plaster of paris as an implant in the infrabony environment: a preliminary study. Journal of periodontology. 1969; 40: 11-13.

DOI: 10.1902/jop.1969.40.1.11

Google Scholar

[4] AlGhamdi A ST. Osteotome maxillary sinus lift using bovine bone and calcium sulfate: a case series. Clinical implant dentistry and related research. 2013; 15: 153-159.

DOI: 10.1111/j.1708-8208.2011.00420.x

Google Scholar

[5] Peltier LF, Bickel EY, Lillo R, Thein MS. The use of plaster of Paris to fill defects in bone. Annals of surgery. 1957; 146: 61.

DOI: 10.1097/00000658-195707000-00007

Google Scholar

[6] Coetzee AS. Regeneration of bone in the presence of calcium sulfate[J]. Archives of Otolaryngology. 1980; 106: 405-409.

DOI: 10.1001/archotol.1980.00790310029007

Google Scholar

[7] Hughes E, Yanni T, Jamshidi P, Grover L. MInorganic cements for biomedical application: calcium phosphate, calcium sulphate and calcium silicate. Advances in Applied Ceramics. 2015; 114: 65-76.

DOI: 10.1179/1743676114y.0000000219

Google Scholar

[8] Gao C, Huo S, Li X, You X, Zhang Y, Gao J. Characteristics of calcium sulfate/gelatin composite biomaterials for bone repair. Journal of Biomaterials Science, Polymer Edition. 2007; 18: 799-824.

DOI: 10.1163/156856207781367710

Google Scholar

[9] Sprio S, Tampieri A, Celotti G, Landi E. Development of hydroxyapatite/calcium silicate composites addressed to the design of load-bearing bone scaffolds. Journal of the mechanical behavior of biomedical materials. 2009; 2: 147-155.

DOI: 10.1016/j.jmbbm.2008.05.006

Google Scholar

[10] Gao C, Huo S, Li X, You X, Zhang Y, Gao J. Characteristics of calcium sulfate/gelatin composite biomaterials for bone repair. Journal of Biomaterials Science, Polymer Edition. 2007; 18: 799-824.

DOI: 10.1163/156856207781367710

Google Scholar

[11] Chen Z, Kang L, Meng Q, Liu H, Wang Z, Guo Z, Cui F. Degradability of injectable calcium sulfate/mineralized collagen-based bone repair material and its effect on bone tissue regeneration. Materials Science and Engineering: C. 2014; 45: 94-102.

DOI: 10.1016/j.msec.2014.08.060

Google Scholar

[12] Kim YK, Lee JY, Kim SG, Lim SC. Guided bone regeneration using demineralized allogenic bone matrix with calcium sulfate: case series. The journal of advanced prosthodontics. 2013; 5: 167-71.

DOI: 10.4047/jap.2013.5.2.167

Google Scholar

[13] Hu N, Chen Z, Liu X, Liu H, Lian X, Wang X, Cui F. Mechanical properties and in vitro bioactivity of injectable and self-setting calcium sulfate/nano-HA/collagen bone graft substitute. Journal of the mechanical behavior of biomedical materials. 2012; 12: 119-128.

DOI: 10.1016/j.jmbbm.2011.12.007

Google Scholar

[14] Zhuang J, Lin J, Li J, Weng W, Cheng K, Wang H. Alternating potentials assisted electrochemical deposition of mineralized collagen coatings. Colloids & Surfaces B Biointerfaces, 2005; 136, 479.

DOI: 10.1016/j.colsurfb.2015.09.050

Google Scholar