Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering

Fany Quemeneur; Corine Tourne-Peteilh; Christophe Drouet; Agnès Dupret-Bories; Audrey Tourrette; Sylvie Begu; Sophie Girod Fullana

doi:10.4028/www.scientific.net/KEM.758.145

Paper Titles

Antibiotic Containing Poly Lactic Acid/Hydroxyapatite Biocomposite Coatings for Dental Implant Applications
p.120

Development of Controllable Simvastatin-Releasing PLGA/β-TCP Composite Microspheres Sintered Scaffolds as Synthetic Bone Substitutes
p.126

Strategies to Improve Bioactivity of Hydroxyapatite Bone Scaffolds
p.132

Preparation and Evaluation of Calcium Sulfate/Collagen Composite Pellets
p.138

Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering
p.145

Hydroxyapatite Bioceramics Reinforced with Silica-Coated Graphene
p.150

Conversion of Calcified Algae (Halimeda sp) and Hard Coral (Porites sp) to Hydroxyapatite
p.157

Development of Ultra-Thin Opaque White Hydroxyapatite Sheet for Restoration of Enamel and Aesthetic Treatments of Teeth
p.162

Fabrication of Sodium-Substituted Hydroxyapatite Ceramics via Ultrasonic Spray-Pyrolysis Route and their Material Properties
p.166

HomeKey Engineering MaterialsKey Engineering Materials Vol. 758Foam-Based Bionanocomposite Scaffold for Bone...

Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering

Abstract:

The repair of large bone defects is a major clinical problem for which tissue engineering (association of a biomaterial and cells) constitutes a valuable alternative. In this domain, the architecture and the mechanical properties of the 3D scaffold aimed to support cells is of key importance to succeed in bone reconstruction. In this study, we aim to design and evaluate a bionanocomposite foam-based scaffold, exhibiting all the desired biofunctional attributes of biocompatibility, bioactivity, osteoconduction/induction, combined with potential release properties. To perform this, 2 components have been associated: (i) a biopolymer, pectin, incorporating (ii) calcium phosphate nanoparticules to provide bone apatite nucleation sites, mechanical reinforcement, and to play the role of potential drug reservoir. The goal of this study was to determine the feasibility of obtention of such bionanocomposite by foam-templating, and to study the influence of mineral particules ratio on pectin foam and final scaffold 3D architecture and properties.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volume 758)

Pages:

145-149

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.758.145

Citation:

Cite this paper

Online since:

November 2017

Authors:

Fany Quemeneur, Corine Tourne-Peteilh, Christophe Drouet, Agnès Dupret-Bories, Audrey Tourrette, Sylvie Begu, Sophie Girod Fullana*

Keywords:

3D Scaffold, Bionanocomposite, Foam, Maxillofacial Reconstruction, Nanocrystalline Apatite, Pectin

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] Cordeiro PG, Santamaria E. A classification system and algorithm for reconstruction of maxillectomy and midfacial defects. Plastic and reconstructive surgery. 105(7) (2000) 2331-46.

DOI: 10.1097/00006534-200006000-00004

Google Scholar

[2] Werle AH, Tsue TT, Toby EB, Girod DA. Osteocutaneous radial forearm free flap: its use without significant donor site morbidity. Otolaryngology-head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 123(6) (2000).

DOI: 10.1067/mhn.2000.110865

Google Scholar

[3] Chanchareonsook N; Junker R; Jongpaiboonkit L et al. Tissue- Engineered Mandibular Bone Reconstruction for Continuity Defects: A Systematic Approach to the Literature. Tissue Engineering Part B-Reviews 20(2) (2014) 147-162.

DOI: 10.1089/ten.teb.2013.0131

Google Scholar

[4] Payne K.; Balasundaram, I; Deb, S; et al. Tissue engineering technology and its possible applications in oral and maxillofacial surgery. British Journal Of Oral & Maxillofacial Surgery 52(1) (2014) 7-15.

DOI: 10.1016/j.bjoms.2013.03.005

Google Scholar

[5] Ceccaldi C, and Bushkalova R, Cussac Dl, Duployer B et al, Sallerin B and Girod Fullana Sophie. Elaboration and evaluation of alginate foam scaffolds for soft tissue engineering. International Journal of Pharmaceutics 524 (1–2) (2017)433-442.

DOI: 10.1016/j.ijpharm.2017.02.060

Google Scholar

[6] Munarin, F.; Tanzi, M. C.; Petrini, P. Advances in biomedical applications of pectin gels. International Journal Of Biological Macromolecules 55 (2013) 307-307.

DOI: 10.1016/j.ijbiomac.2013.01.008

Google Scholar

[7] Munarin, F.; Petrini, P.; Gentilini, R.; et al. Micro- and nano-hydroxyapatite as active reinforcement for soft biocomposites. International Journal Of Biological Macromolecules 72 (2015) 199-209.

DOI: 10.1016/j.ijbiomac.2014.07.050

Google Scholar

[8] S. Girod Fullana, H. Ternet, M. Freche, J.L. Lacout, F. Rodriguez. Controlled release properties and final macroporosity of a pectin microspheres - calcium phosphate composite bone cement. Acta Biomaterialia 6 (2010) 2294-2300.

DOI: 10.1016/j.actbio.2009.11.019

Google Scholar

[9] Rey, C; Combes, C; Drouet, C; et al. Surface properties of biomimetic nanocrystalline apatites; applications in biomaterials. Progress In Crystal Growth And Characterization Of Materials 60(3-4) (2014) 63-73.

DOI: 10.1016/j.pcrysgrow.2014.09.005

Google Scholar

[10] J. Gomez-Morales, M. Lafisco, J.M. Delgado-Lopez, S. Sarda, C. Drouet. Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects. Progress in Crystal Growth and Characterization of Materials 59 (2013).

DOI: 10.1016/j.pcrysgrow.2012.11.001

Google Scholar

[11] A.G. Mikos, G. Sarakinos, M.D. Lyman, D.E. Ingber, J.P. Vacanti, R. Langer. Prevascularization of porous biodegradable polymers. Biotechnol. Bioeng. 42 (1993) 716-723.

DOI: 10.1002/bit.260420606

Google Scholar