Hydroxyapatite Bioceramics Reinforced with Silica-Coated Graphene

Zhong Li; Shu Guang Bi; Rutiao Li; Khiam Aik Khor

doi:10.4028/www.scientific.net/KEM.758.150

Paper Titles

Development of Controllable Simvastatin-Releasing PLGA/β-TCP Composite Microspheres Sintered Scaffolds as Synthetic Bone Substitutes
p.126

Strategies to Improve Bioactivity of Hydroxyapatite Bone Scaffolds
p.132

Preparation and Evaluation of Calcium Sulfate/Collagen Composite Pellets
p.138

Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering
p.145

Hydroxyapatite Bioceramics Reinforced with Silica-Coated Graphene
p.150

Conversion of Calcified Algae (Halimeda sp) and Hard Coral (Porites sp) to Hydroxyapatite
p.157

Development of Ultra-Thin Opaque White Hydroxyapatite Sheet for Restoration of Enamel and Aesthetic Treatments of Teeth
p.162

Fabrication of Sodium-Substituted Hydroxyapatite Ceramics via Ultrasonic Spray-Pyrolysis Route and their Material Properties
p.166

Fabrication of Levothyroxine Particles Encapsulated with Apatite
p.172

HomeKey Engineering MaterialsKey Engineering Materials Vol. 758Hydroxyapatite Bioceramics Reinforced with...

Hydroxyapatite Bioceramics Reinforced with Silica-Coated Graphene

Abstract:

Challenges facing graphene-reinforced composites include insufficient interfacial strengths, filler agglomeration, and their potential cytotoxicity. To tackle these challenges, silica-coated graphene (S-G) is used to toughen a representative bioceramic, hydroxyapatite (HA), and HA-based composites were prepared by park plasma sintering. By adding 2 wt.% silica-coated graphene oxide, a precursor to S-G, the fracture toughness of HA could be increased by 84%. Compared with graphene/HA pellets, the S-G/HA samples showed superior mechanical properties. In addition, the incorporation of S-G could promote the proliferation and differentiation of human osteoblast-like cells MG63, and showed no adverse effect on their viability. Therefore, the multifunctional bioceramic-based materials presented here possess great potential in load-bearing orthopedic implants.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volume 758)

Pages:

150-154

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.758.150

Citation:

Cite this paper

Online since:

November 2017

Authors:

Zhong Li, Shu Guang Bi, Rutiao Li, Khiam Aik Khor*

Keywords:

Biocompatibility, Fracture Toughness, Graphene Oxide, Hydroxyapatite, Silica, Spark Plasma Sintering

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] Z. Li, N.W. Khun, X. -Z. Tang, E. Liu, K.A. Khor, Mechanical, tribological and biological properties of novel 45S5 Bioglass® composites reinforced with in situ reduced graphene oxide, J. Mech. Behav. Biomed. Mater. 65 (2017) 77–89.

DOI: 10.1016/j.jmbbm.2016.08.007

Google Scholar

[2] Z. Li, X. -Z. Tang, W. Zhu, B.C. Thompson, M. Huang, J. Yang, X. Hu, K.A. Khor, Single-step process toward achieving superhydrophobic reduced graphene oxide, ACS Appl. Mater. Interfaces 8 (2016) 10985-10994.

DOI: 10.1021/acsami.6b01227

Google Scholar

[3] Y. Yang, S. Qiu, W. Cui, Q. Zhao, X. Cheng, R.K.Y. Li, X. Xie, Y. -W. Mai, A facile method to fabricate silica-coated carbon nanotubes and silica nanotubes from carbon nanotubes templates, J. Mater. Sci. 44 (2009) 4539-4545.

DOI: 10.1007/s10853-009-3687-1

Google Scholar

[4] G.C. Reilly, S. Radin, A.T. Chen, P. Ducheyne, Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal stem cells to 45S5 bioactive glass, Biomaterials 28 (2007) 4091-4097.

DOI: 10.1016/j.biomaterials.2007.05.038

Google Scholar

[5] J.L. Xu, K.A. Khor, J.J. Sui, J. Zhang, T.L. Tan, W.N. Chen, Comparative proteomics profile of osteoblasts cultured on dissimilar hydroxyapatite biomaterials: An iTRAQ‐coupled 2‐D LC‐MS/MS analysis, Proteomics 8 (2008) 4249-4258.

DOI: 10.1002/pmic.200800103

Google Scholar