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HomeKey Engineering MaterialsKey Engineering Materials Vol. 758Fabrication of Levothyroxine Particles...

Fabrication of Levothyroxine Particles Encapsulated with Apatite

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Abstract:

Apatite nuclei were obtained by raising pH of an acellular simulated body fluid (SBF). The apatite nuclei and levothyroxine particles were dispersed in an ultrapure water and the apatite nuclei were attached to the surface of the levothyroxine particles. By soaking in SBF, apatite formation was induced by the apatite nuclei located on the surface of the levothyroxine particles and the levothyroxine particles were encapsulated with apatite. We evaluated release behavior of levothyroxine in phosphate buffered saline.

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Bioceramics 29

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Periodical:

Key Engineering Materials (Volume 758)

Pages:

172-177

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.758.172

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Online since:

November 2017

Authors:

Takeshi Yabutsuka*, Shigeomi Takai, Takeshi Yao

Keywords:

Apatite Nuclei, Encapsulation, Hydroxyapatite, Levothyroxine, Simulated Body Fluid (SBF)

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© 2017 Trans Tech Publications Ltd. All Rights Reserved

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