Kinetics and the Theoretical Aspects of Drug Release from PLA/HAp Thin Films

Abstract:

The theory of dissolution kinetics of gentamicin from polylactic acid-hydroxyapatite thin film composites is spotlighted with the combination of diffusion and polymer degradation modeling. The use of various mathematical models, characterizing diffusion, dissolution or/and erosion prevalence as well as a mix of dissolution-diffusion rate processes were employed in order to compare theory with experimental data. A number of factors influence the release kinetics of gentamicin from medical drug release systems and devices. It is difficult to have a single mathematical model that takes all these factors into account. It is shown that the degradation of the polymer matrix plays the biggest role in the release kinetics of polymer-ceramics thin film composites. It was also observed that multistage drug release form these devices depends also on the degradation kinetics of the polymer matrix. The effect of pH and device sizes were not studied but could also be of interest in future studies.

• Periodical: Key Engineering Materials (Volume 758)
• Pages: 113-119
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.758.113
• Online since: November 2017
• Authors: Innocent Jacob Macha*, Besim Ben-Nissan, Wolfgang H. Müller
• Keywords: Antibiotic, Coral-Derived Hydroxyapatite, Drug Delivery, Drug Dissolution, Kinetics, Thin Film

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