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Loading of Fluvastatin onto Gelatin-Coated Titanium Implants

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Abstract:

We aimed to investigate the effects of alumina blasting and alkaline treatment on the immobilization of gelatin-fluvastatin complexes on titanium disks. Blasted titanium disks were submicron-sized porous while the alkaline treated disks were submicron-and nanoporous. XPS analysis revealed homogeneous coverage of titanium disks with a gelatin layer on top of an intermediate polydopamine treatment. The highest amount of fluvastatin immobilization was observed on top of alkaline treated titanium as compared to the blasted disk. A combination of alkaline pre-treatment followed by polydopamine-assisted immobilization of gelatin facilitated optimal loading of fluvastatin onto titanium dental implants.

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Periodical:

Key Engineering Materials (Volume 782)

Pages:

233-237

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.782.233

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Online since:

October 2018

Authors:

Shinji Takemoto*, Kaori Sasaki, Shiho Sugawara, Setsuo Saitoh, Tomofumi Sawada, Masayuki Taira, Koji Tanabe, Masao Yoshinari, Masayuki Hattori, John J. Jansen, Sander G.G. Leeuwenburgh

Keywords:

Dental Implant, Fluvastatin, Gelatin, Localized Drug Delivery, Surface Morphology, Titanium, X-Ray Photoelectron Spectroscopy

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© 2018 Trans Tech Publications Ltd. All Rights Reserved

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