Cotton-Wool-Like Resorbable Bone Void Fillers Containing β-TCP and Calcium Carbonate Particles

Naoki Osada; Masashi Makita; Yasutoshi Nishikawa; Toshihiro Kasuga

doi:10.4028/www.scientific.net/KEM.782.53

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Cotton-Wool-Like Resorbable Bone Void Fillers Containing β-TCP and Calcium Carbonate Particles
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HomeKey Engineering MaterialsKey Engineering Materials Vol. 782Cotton-Wool-Like Resorbable Bone Void Fillers...

Cotton-Wool-Like Resorbable Bone Void Fillers Containing β-TCP and Calcium Carbonate Particles

Abstract:

Cotton-wool-like bioresorbable bone void fillers consisting of β-tricalcium phosphate (β-TCP), siloxane-containing vaterite (SiV) and poly (_L-lactic acid) (PLLA) was prepared by an electrospinning method. The fibers, which were 50 ~ 150 μm-width with 10 ~ 30 μm-thickness, were entwined. The resulting cotton-wool-like material showed mechanical flexibility and excellent shapability; it showed easy, excellent mechanical-fixation in defects. The in vivo performance of this material was examined in the distal femur in New Zealand white rabbits. It was evaluated using micro CT and histologic analyses at time points of 6 and 12 weeks. These analyses of the defect sites verified normal healing response and new bone formation. The in vivo testing with rabbits showed good biocompatibility and excellent osteogenic ability.

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Periodical:

Key Engineering Materials (Volume 782)

Pages:

53-58

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.782.53

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Online since:

October 2018

Authors:

Naoki Osada, Masashi Makita, Yasutoshi Nishikawa, Toshihiro Kasuga

Keywords:

Calcium Carbonate, Calcium Phosphate, Electrospinning, Filler, Poly(L-Lactic Acid)

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