A Comparative Study of Granular Agglomeration between 3D Printed Hydroxyapatite and Commercial Bone Graft Granules

Abstract:

Granule characteristics and the agglomeration ability of 3D printed hydroxyapatite granules (3DP HA) when contacting water were compared to those of commercial bone graft granules based on hydroxyapatite/β-tricalcium phosphate/collagen mixture (Sunmax). Microstructure, phase composition, water absorption and granular agglomeration of the granules were characterized. SEM showed that the granule sizes of Sunmax were in the range of 0.8-1.5 mm whereas that of 3DP HA was relatively more uniform at about 1 mm. 3DP HA granules comprised the weaving of numerous minute crystals containing large pores and having high porosity while Sunmax granules were crushed granules and having low porosity. XRD analysis confirmed that Sunmax granules were biphasic hydroxyapatite and β-tricalcium phosphate while 3DP HA granules were monophasic hydroxyapatite. Sunmax granules exhibited greater agglomeration volume than that of 3DP HA granules. However, the water absorption of 3DP HA granules was greater than that of Sunmax granules. The greater agglomeration ability of Sunmax granules was likely due to the collagen constituent of the granules which could act as adhesive to bind granules together in addition to water capillary action. In contrast, 3DP HA granules formed the agglomeration by the water film due to the capillary action only so the efficiency was lower although the water absorption was greater.

• Periodical: Key Engineering Materials (Volume 798)
• Pages: 83-87
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.798.83
• Online since: April 2019
• Authors: Faungchat Thammarakcharoen, Ariya Yampakdee, Bovornwut Buranawat, Jintamai Suwanprateeb*
• Keywords: Bone Graft, Granular Agglomeration, Hydroxyapatite, Water Absorption

References

[1] W. Wang and K.W.K. Yeung, Bone grafts and biomaterials substitutes for bone defect repair: A review, Bioact. Mater., 2 (2017) 224-247.

DOI: 10.1016/j.bioactmat.2017.05.007

[2] J.D. Kassolis, P.S. Rosen and M.A. Reynolds, Alveolar ridge and sinus augmentation utilizing platelet-rich plasma in combination with freeze-dried bone allograft: case series, J. Periodontol., 71 (2000) 1654-1661.

DOI: 10.1902/jop.2000.71.10.1654

[3] J. Suwanprateeb, F. Thammarakcharoen, K. Wasoontararat and W. Suvannapruk, Influence of printing parameters on the transformation efficiency of 3D-printed plaster of paris to hydroxyapatite and its properties, Rapid Prototyping J., 18 (2012) 490-499.

DOI: 10.1108/13552541211272036

[4] P. Kijartorn, F. Thammarakcharoen, J. Suwanprateeb and B. Buranawat, The use of three dimensional printed hydroxyapatite granules in alveolar ridge preservation, Key Eng. Mater., 751 (2017) 663-667.

DOI: 10.4028/www.scientific.net/kem.751.663

[5] G. Turnbull, J. Clarke, F. Picard, P. Riches, L. Jia. F. Han, B. Li and W. Shu, 3D bioactive composite scaffolds for bone tissue engineering, Bioact. Mater, 3 (2018) 278-314.

DOI: 10.1016/j.bioactmat.2017.10.001

[6] D.S. Oh, Y.J. Kim, M.H. Hong, M.H. Han and K.K. Kim, Effect of capillary action on bone regeneration in micro-channeled ceramic scaffolds, Ceram. Int., 40 (2014) 9583-9589.

DOI: 10.1016/j.ceramint.2014.02.033

[7] E.J.R. Parteli, J. Schmidt, C. Blϋmel, K. Wirth and W. Peukert, Attractive particle interaction forces and packing density of fine glass powders, Sci. Rep., 4 (2014) 1-7.

DOI: 10.1038/srep06227

[8] H.T. Shiu, B. Goss, C. Lutton, R. Crawford and Y. Xiao, Formation of blood clot on biomaterial implants influences bone healing, Tissue Eng. Part B Rev., 20 (2014) 697-712.

DOI: 10.1089/ten.teb.2013.0709