Development and Evaluation of Thermally-Crosslinked Mucoadhesive Gantrez^TM S-97/Polyvinyl Alcohol/ Hyaluronic Acid-Catechol Nanofibers

Abstract:

This study aimed to develop novel thermally crosslinked mucoadhesive nanofibers. The nanofiber patches were composed of mucoadhesive polymers which were catechol-bearing hyaluronic acid (HA-cat) and copolymer of methyl vinyl ether and maleic anhydride (Gantrez^TM, GT). Polyvinyl alcohol was used to improve the nanofiber properties. The nanofibers were prepared from a polymer mixture of 20 %wt GT, 10 %wt PVA, and 2 %wt HA-cat at different ratios using an electrospinning technique. Crosslinking process was performed by heat treatment at 130 °C for various durations. The appearances and chemical characteristics of the patch was evaluated using scanning electron microscope (SEM) and attenuated total reflectance Fourier-transformed infrared spectroscopy (ATR-FTIR), respectively. Moreover, the percentage of water insolubilization, tensile strength, and mucoadhesive property of the electrospun nanofibers were evaluated. Different polymer ratios provided identical nanoscale fibers. The patch prepared at the GT:PVA:HA-cat ration of 1:1:2 which provided the highest amount of catechol was selected. The optimal crosslinking time was 2 h under 130 °C in which the fiber diameters were not altered, and the highest percentage of water insolubilization was observed. Hydrogen and ester bond formation were established from the ATR-FTIR spectrum of the crosslinked patch. The patch could resist the force applied up to 4.82±0.46 N prior to deformation. In addition, the maximum detachment force from porcine buccal mucosa was 0.08±0.01 N. After all, the prepared electrospun mucoadhesive nanofibers may be a favorable mucoadhesive material for transmucosal drug delivery.

• Periodical: Key Engineering Materials (Volume 859)
• Pages: 208-213
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.859.208
• Online since: August 2020
• Authors: Chaiyakarn Pornpitchanarong, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat, Prasopchai Patrojanasophon*
• Keywords: Catechol-Bearing Hyaluronic Acid, Maleic Anhydride Copolymer, Methyl Vinyl Ether, Mucoadhesive Nanofiber, Thermal Crosslink

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