Types of Solid Lipids on Physical Stability of Resveratrol-Loaded Nanostructured Lipid Carriers

Abstract:

Resveratrol (Res) loaded nanostructured lipid carriers (NLCs) were prepared by high shear homogenization and ultrasonication technique. Caprylic/capric glyceride (IM) was used as a liquid lipid, while glyceryl monostearate (GMS), beeswax (BW), palmitic acid (PA) and myristic acid (MA) at various concentrations (5, 10, 15, and 20 %w/w) were solid lipids. Polyoxyethylene 20 sorbitan monooleate or polysorbate 80 (Tween^® 80) was use as a surfactant. The results showed that all concentration of PA and MA can be prepared the smaller particle NLC than that using GMS and BW according to the small molecule of MA and PA. The zeta potential of Res loaded NLCs were negative charge (-24.30 to -37.80 mV), which could be considered as a stable system. The stability studies revealed that NLCs with MA and PA showed a - high stability in particle size and zeta potential after storage at 40 ± 2°C /75 %RH for 3 months. These results suggested the MA and PA were suitable solid lipids for the NLCs preparation which have potential to be a nanoparticulate carrier for Res delivery.

• Periodical: Key Engineering Materials (Volume 859)
• Pages: 203-207
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.859.203
• Online since: August 2020
• Authors: Benchawan Chamsai*, Wipada Samprasit, Praneet Opanasopit, Pontip Benjasirimongkol, Pornsak Sriamornsak
• Keywords: Nanoparticles, Nanostructured Lipid Carriers (NLCs), Resveratrol, Stability

References

[1] M.D. Joshi, R.H. Prabhu, V.B. Patravale, Fabrication of Nanostructured Lipid Carriers (NLC)-Based Gels from Microemulsion Template for Delivery Through Skin, in: Weissig V., Elbayoumi T. (Eds), Pharmaceutical Nanotechnology. Methods in Molecular Biology, vol 2000. Humana, New York, NY, 2019, pp.279-292.

DOI: 10.1007/978-1-4939-9516-5_19

[2] P Ganesana and D Narayanasamy, Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery, Sustain Chem Pharm. 6 (2017) 37–56.

DOI: 10.1016/j.scp.2017.07.002

[3] P Benjasirimongkol and P Sriamornsak, Stability study of resveratrol-loaded emulsions using pectin as an emulsifier, Asian J Pharm Sci. 11(2016) 199-200.

DOI: 10.1016/j.ajps.2015.11.037

[4] A Khosa, S Reddi and R N Saha, Nanostructured lipid carriers for site-specific drug delivery, Biomedicine & Pharmacotherapy. 103(2018) 598–613.

DOI: 10.1016/j.biopha.2018.04.055

[5] J-K Choi, C H Park and J Lee, Effect of polymer molecular weight on nanocomminution of poorly Soluble Drug, Drug Delivery. 15(2008) 347–353.

DOI: 10.1080/10717540802039113

[6] L Wu, J Zhang and W Watanabe, Physical and chemical stability of drug nanoparticles, Adv Drug Deliv Rev. 63(2011) 456-469.

[7] N Rosita, D Setyawan, W Setyawan, S Mrtodihardjo, Physical characterization of beeswax and glyceryl monostearat binary system to predict characteristics of solid lipid nanoparticle (SLN) loaded para methoxy cinnamic acid (PMCA), Int J Pharm Pharm Sci, 6(Suppl 2)(2014) 939-945.