Effect of Modified Hydroxypropyl Tapioca Starch and Percentage of Drug Loading on Physical Property of Paracetamol Tablet

Abstract:

The objective of this study was to investigate the effect of modified hydroxypropyl tapioca starch (HPTS) and % drug loading on physical property of tablet. Paracetamol was used as model drug because of its poor compressibility. The filler ability of modified HPTS such as hydroxyl propyl oxidized tapioca starch (HPOTS), hydroxyl propyl crosslinked tapioca starch (HPCTS) and pregelatinized tapioca starch (PTS) were evaluated and compared with the commercial starch (Starch 1500^®). Tablets were prepared by direct compression method and the percent drug loading were 15, 30, 45, 60, 75%. For modified HPTS, the hardness of the tablets tended to decrease when the concentration of paracetamol increased. At drug concentrations of 15-30%, HPOTS exhibited good performance of tablet as indicated by the high hardness, low friability and acceptable disintegration time. The obtained results were better than HPTS and comparable to Starch 1500^®. Moreover, the results revealed that tablet containing PTS provided the highest hardness and prolonged disintegration time (>30 min) while tablet containing HPCTS showed rapid disintegration time (<2 min). Therefore, modified HPTS disclosed promising properties for application as tablet filler

• Periodical: Key Engineering Materials (Volume 859)
• Pages: 3-8
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.859.3
• Online since: August 2020
• Authors: Vipaluk Patomchaiviwat, Sontaya Limmatvapirat, Chaisai Sirisapaya, Rohanee Kolae, Kulmanee Anantakul, Suchada Piriyaprasarth*
• Keywords: Filler, Hydroxylpropyl Tapioca Starch, Modified Starch, Pregelatinized Starch

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