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Development of Chitosan-Gelatin Nanofibers with Cellulose Nanocrystals for Skin Protection Applications

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Abstract:

In this work, natural-based and biodegradable nanofibers were produced by electrospinning for drug delivery and wound dressing applications, using gelatin (Gel), chitosan (CS), cellulose nanocrystals (CNC) and natural propolis extract. The polymeric formulations and electrospinning parameters were optimized, resulting in the development of Gel/CS nanofibers with mean diameters of 97 nm. CNC were successfully introduced into the optimized Gel/CS solution and the viscosity and conductivity values were recorded. The developed nanofibers were characterized using FESEM, ATR-FTIR, TGA and WCA. The incorporation of different CNC concentrations improved the solutions’ electrospinnability and the membranes’ physical integrity. Defect-free and uniform Gel/CS/CNC nanofibers were observed by FESEM images, and the fibers’ diameters slight increased. The hydrophilic character was maintained after the CNC incorporation. Finally, Gel/CS/CNC/Propolis nanofibers demonstrated antibacterial activity against both Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria.

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Periodical:

Key Engineering Materials (Volume 893)

Pages:

45-55

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.893.45

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Online since:

July 2021

Authors:

Ana S. Ribeiro, Sofia M. Costa, Diana P. Ferreira*, Houcine Abidi, Raul Fangueiro

Keywords:

Antibacterial Activity, Biodegradable Polymers, Cellulose Nanocrystals (CNC), Drug Delivery Systems, Electrospinning, Nanofibers, Natural Extracts, Wound Dressing

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© 2021 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] A. Raza, Y. Li, J. Sheng, J. Yu, B. Ding, Protective Clothing Based on Electrospun Nanofibrous Membranes, in: B. Ding, J. Yu (Eds.), Electrospun Nanofibers for Energy and Environmental Applications, Springer, Berlin, Heidelberg, 2014, pp.355-369.

DOI: 10.1007/978-3-642-54160-5_14

Google Scholar

[2] D.P. Ferreira, S.M. Costa, H.P. Felgueiras, R. Fangueiro, Smart and Sustainable Materials for Military Applications Based on Natural Fibres and Silver Nanoparticles, Key Eng. Mater. 812 (2019) 66–74.

DOI: 10.4028/www.scientific.net/kem.812.66

Google Scholar

[3] A.-M. Croitoru, D. Ficai, A. Ficai, N. Mihailescu, E. Andronescu, C.F. Turculet, Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications, Mater. (Basel, Switzerland). 13 (2020) 2407.

DOI: 10.3390/ma13102407

Google Scholar

[4] M.A. Teixeira, M.C. Paiva, M.T.P. Amorim, A.H.P. Felgueiras, Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing., Nanomater. (Basel, Switzerland). 10 (2020) 557.

DOI: 10.3390/nano10030557

Google Scholar

[5] H. Samadian, S. Zamiri, A. Ehterami, S. Farzamfar, A. Vaez, H. Khastar, M. Alam, A. Ai, H. Derakhshankhah, Z. Allahyari, A. Goodarzi, M. Salehi, Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies, Sci. Rep. 10 (2020) 8312.

DOI: 10.1038/s41598-020-65268-7

Google Scholar

[6] D.P. Ferreira, D.S. Conceicao, R.C. Calhelha, T. Sousa, R. Socoteanu, I.C.F.R. Ferreira, L.F. Vieira Ferreira, Porphyrin dye into biopolymeric chitosan films for localized photodynamic therapy of cancer, Carbohydr. Polym. 151 (2016) 160–171.

DOI: 10.1016/j.carbpol.2016.05.060

Google Scholar

[7] N. Amiri, Z. Rozbeh, T. Afrough, S.A. Sajadi Tabassi, A. Moradi, J. Movaffagh, Optimization of Chitosan-Gelatin Nanofibers Production: Investigating the Effect of Solution Properties and Working Parameters on Fibers Diameter, Bionanoscience. 8 (2018) 778–789.

DOI: 10.1007/s12668-018-0540-5

Google Scholar

[8] N. Cai, C. Li, C. Han, X. Luo, L. Shen, Y. Xue, F. Yu, Tailoring mechanical and antibacterial properties of chitosan/gelatin nanofiber membranes with Fe3O4 nanoparticles for potential wound dressing application, Appl. Surf. Sci. 369 (2016) 492–500.

DOI: 10.1016/j.apsusc.2016.02.053

Google Scholar

[9] A.D. Juncos Bombin, N.J. Dunne, H.O. McCarthy, Electrospinning of natural polymers for the production of nanofibres for wound healing applications, Mater. Sci. Eng. C. 114 (2020) 110994.

DOI: 10.1016/j.msec.2020.110994

Google Scholar

[10] H. Kargarzadeh, M. Mariano, J. Huang, N. Lin, I. Ahmad, A. Dufresne, S. Thomas, Recent developments on nanocellulose reinforced polymer nanocomposites: A review, Polymer (Guildf). 132 (2017) 368–393.

DOI: 10.1016/j.polymer.2017.09.043

Google Scholar

[11] C. Zhou, R. Chu, R. Wu, Q. Wu, Electrospun Polyethylene Oxide / Cellulose Nanocrystal Composite Nanofibrous Mats with Homogeneous and Heterogeneous Microstructures, Biomacromolecules. 12 (2011) 2617–2625.

DOI: 10.1021/bm200401p

Google Scholar

[12] I. Przybyłek, T.M. Karpiński, Antibacterial Properties of Propolis, Molecules. 24 (2019) (2047).

DOI: 10.3390/molecules24112047

Google Scholar

[13] D.M. Ridolfi, A.P. Lemes, S. de Oliveira, G.Z. Justo, M. V Palladino, N. Durán, Electrospun poly(ethylene oxide)/chitosan nanofibers with cellulose nanocrystals as support for cell culture of 3T3 fibroblasts, Cellulose. 24 (2017) 3353–3365.

DOI: 10.1007/s10570-017-1362-2

Google Scholar

[14] A. Hivechi, S.H. Bahrami, R.A. Siegel, Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers, Int. J. Biol. Macromol. 124 (2019) 411–417.

DOI: 10.1016/j.ijbiomac.2018.11.214

Google Scholar

[15] K. Jalaja, D. Naskar, S.C. Kundu, N.R. James, Potential of electrospun core–shell structured gelatin–chitosan nanofibers for biomedical applications, Carbohydr. Polym. 136 (2016) 1098–1107.

DOI: 10.1016/j.carbpol.2015.10.014

Google Scholar

[16] P. Chen, L. Liu, J. Pan, J. Mei, C. Li, Y. Zheng, Biomimetic composite scaffold of hydroxyapatite/gelatin-chitosan core-shell nanofibers for bone tissue engineering, Mater. Sci. Eng. C. 97 (2019) 325–335.

DOI: 10.1016/j.msec.2018.12.027

Google Scholar

[17] S. Habibi, K. Hajinasrollah, Electrospinning of Nanofibers Based on Chitosan/Gelatin Blend for Antibacterial Uses, Russ. J. Appl. Chem. 91 (2018) 877–881.

DOI: 10.1134/s1070427218050191

Google Scholar

[18] H. Kargarzadeh, R. M. Sheltami, I. Ahmad, I. Abdullah, A. Dufresne, Cellulose nanocrystal: A promising toughening agent for unsaturated polyester nanocomposite, Polymer (Guildf). 56 (2015) 346–357.

DOI: 10.1016/j.polymer.2014.11.054

Google Scholar

[19] H. Celebi, A. Kurt, Effects of processing on the properties of chitosan/cellulose nanocrystal films, Carbohydr. Polym. 133 (2015) 284–293.

DOI: 10.1016/j.carbpol.2015.07.007

Google Scholar

[20] A. Hivechi, S.H. Bahrami, R.A. Siegel, Drug release and biodegradability of electrospun cellulose nanocrystal reinforced polycaprolactone, Mater. Sci. Eng. C. 94 (2019) 929–937.

DOI: 10.1016/j.msec.2018.10.037

Google Scholar

[21] J. Liu, C.-K. Liu, E. Brown, Development and Characterization of Genipin Cross-linked Gelatin Based Composites Incorporated with Vegetable-Tanned Collagen Fiber (VCF), J. Am. Leather Chem. Assoc. 112 (2017) 410–419.

Google Scholar

[22] X. Liu, T. Lin, Y. Gao, Z. Xu, C. Huang, G. Yao, L. Jiang, Y. Tang, X. Wang, Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing., J. Biomed. Mater. Res. B. Appl. Biomater. 100 (2012) 1556–1565.

DOI: 10.1002/jbm.b.32724

Google Scholar

[23] A. Verlee, S. Mincke, C. V Stevens, Recent developments in antibacterial and antifungal chitosan and its derivatives, Carbohydr. Polym. 164 (2017) 268–283.

DOI: 10.1016/j.carbpol.2017.02.001

Google Scholar

[24] P. Tyagi, R. Mathew, C. Opperman, H. Jameel, R. Gonzalez, L. Lucia, M. Hubbe, L. Pal, High-Strength Antibacterial Chitosan–Cellulose Nanocrystal Composite Tissue Paper, Langmuir. 35 (2019) 104–112.

DOI: 10.1021/acs.langmuir.8b02655

Google Scholar

[25] J.M. Sforcin, Biological Properties and Therapeutic Applications of Propolis, Phytother. Res. 30 (2016) 894–905.

DOI: 10.1002/ptr.5605

Google Scholar

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