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Fabrication and Pulse Sequences Evaluation of Iron Oxides Nanoparticles as MRI Contrast Agent

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Abstract:

The objective of this in vivo study is to enhance the T2-weighted MRI contrast using superparamagnetic nanoparticles in liver and spleen of rabbits for biomedicine application. Superparamagnetic nanoparticles were synthesized using co-precipitation method. Superparamagnetic nanoparticles were characterized using SEM, EDX, VSM, magnetic resonance relaxation and magnetic resonance imaging (MRI). T1 and T2 relaxations were measured as function of concentration of contrast agents in liver and spleen. High relaxivity ratio r2/r1 showed the efficacy of prepared T2- weighted MRI contrast agent. Rabbits were anesthetized using xylazine and ketamine salts for medical procedure. Ketamine and xylazine were injected with the dose rate of ketamine 25-40 mg/kg and xylazine 2.5-5mg/kg intra-muscularly for veterinary anesthesia. MRI of albino rabbits was executed at 0.35 Tesla using magnetic nanoparticles. FDA approved, 0.2 ml/kg dose of contrast agents was injected in rabbits for MRI scanning. MRI axial and coronal, T1-W and T2-W images of liver and spleen were taken using Spin Echo (SE) at TE=92 and TR=551 and STIR at TE=24 and TR=5170. Spin software was used to estimate the intensity of signal in region of interest induced by magnetic contrast agent. In vivo, MRI study of magnetic contrast agents demonstrated the high T2 -weighted contrast on MRI images of liver and spleen of rabbits. This research also concludes that superparamagnetic nanoparticles may be used as MRI contrast agents for biomedicine application to see the pathology of living organs even at low tesla field.

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Periodical:

Key Engineering Materials (Volume 929)

Pages:

79-88

DOI:

https://doi.org/10.4028/p-2wsh42

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Online since:

August 2022

Authors:

Muhammad Arshad Javid*, Hafiz M. Waseem Afzal, Shahid Khan, Saeed Ahmad Buzdar, Muhammad Nadeem

Keywords:

Contrast Agents, Liver, MRI, Spleen, T2-Weighted

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© 2022 Trans Tech Publications Ltd. All Rights Reserved

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