Preparation of Crosslinked Alginate-Cellulose Derivative Microparticles for Protein Delivery

Abstract:

Microparticle protein delivery system using alginate and cellulose derivative (HPC, HEC and CMC) composite system was prepared using external gelation with vibration technology. Bovine serum albumin (BSA) as a model protein was encapsulated using these biodegradable materials. This preparation showed an increase in encapsulation efficiency in comparison to the samples where pure alginate was used as the encapsulating material. Compared with the other microparticles, the 50:50 alginate/HEC samples exhibited significant encapsulation efficiency. Consequently, its release rate in the acidic medium was comparatively substantial and higher cumulative release in the simulated intestinal fluid (SIF) medium at the end of the dissolution study was observed to be high at around 86.17%.

• Periodical: Key Engineering Materials (Volume 931)
• Pages: 69-75
• DOI: https://doi.org/10.4028/p-o7266l
• Online since: September 2022
• Authors: Rodel Guerrero*, Paul W.S. Heng, Terence P. Tumolva
• Keywords: Alginate, Cellulose, Ionotropic Gelation, Microencapsulation, Protein

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