Reduced Glutathione Antioxidant Stability in Polymer Solutions Toward Wound Bioactive Dressing Application

Abstract:

Reduced glutathione (GSH) is incorporated in polymeric wound dressings to prevent oxidative stress-induced cellular damage and the development of chronic wounds. The present study investigates the influence of polyvinyl alcohol (PVA), polyethylene oxide (PEO), and PVA/PEO blend polymeric solutions on the stability of GSH during the preparations or storage. The stability was studied in three concentrations which were 3%, 5% and 8%, after sometimes between 0 to 7 days. The level of GSH achieved the highest electron donor activity at day 7 in 8% PVA/PEO (95.42%) and 8% PVA (94.27%) solutions, whereas GSH activity decreased when incorporated with PEO solutions. Such a decrease in the GSH activity due to PEO being less water-resistant and hydrolytic degradation susceptibility could expose the GSH to an aqueous environment and lead to the loss of GSH activity. In conclusion, a higher concentration of polymer and less-water resistant polymers can shield the GSH from an aqueous environment and maintain its stability in the polymer solutions used in wound dressing applications.

• Periodical: Key Engineering Materials (Volume 931)
• Pages: 77-82
• DOI: https://doi.org/10.4028/p-ga2z38
• Online since: September 2022
• Authors: Yan Tung Lam, Rania Hussien Al-Ashwal*, Mohd Helmi bin Sani, Sadeq M. Al-Hazmy
• Keywords: Antioxidant, Glutathione, Polymer, Stability, Wound

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