The Application of Aggregation-Induced Emission in Photodynamic Therapy

Abstract:

Aggregation-Induced Emission (AIE) has gone through a rapid development since it’s discovery back in 2001. It is a famous research topic as it shows many advantages compared with traditional fluorescent material struggling with the issue of Aggregation-caused quenching (ACQ), since it only emits fluorescence when gathered. AIE material can provide better sensitivity, better photobleaching resistance and SNR compared with traditional material. AIE material can be applied in the fields of biosensing and bioimaging to replace traditional material with a better performance. This article describes the concept and structure of AIE material, shows types of the material with examples, also introduces the application of AIE material in photodynamic therapy, this article talks about the concept, usage, advantages and drawbacks of applying material with AIE characteristics in photodynamic therapy.

• Periodical: Materials Science Forum (Volume 1058)
• Pages: 79-84
• DOI: https://doi.org/10.4028/p-6bp3c4
• Online since: April 2022
• Authors: Chu Xuan Jin*, Rui Xin Jin
• Keywords: Aggregation-Induced Emission, Bioimaging, Biosensing, Cancerous Cell, Photodynamic Therapy, ROS, Treatment, Tumor

References

[1] Li Y, Wu Q, Kang M, et al. Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles[J]. Biomaterials, 2019, 232:119749.

DOI: 10.1016/j.biomaterials.2019.119749

[2] Hu F, Yuan Y, D Mao, et al. Smart activatable and traceable dual-prodrug for image-guided combination photodynamic and chemo-therapy[J]. Biomaterials, 2017, 144:53-59.

DOI: 10.1016/j.biomaterials.2017.08.018

[3] X Yi, Hu J, Dai J, et al. Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy[J]. ACS Nano, 2021, 15(3).

DOI: 10.1021/acsnano.0c09407.s001

[4] AIE-active theranostic system: selective staining and killing of cancer cells[J]. Chemical Science, (2017).

[5] Wu W, D Mao, Xu S, et al. High-performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy[J]. Materials Horizons, 2017:10. 1039.C7MH00469A.

DOI: 10.1039/c7mh00469a

[6] Lx A, Sz A, Xiao L B, et al. Novel biocompatible AIEgen from natural resources: Palmatine and its bioimaging application - ScienceDirect[J]. Dyes and Pigments, 2020, 184.

DOI: 10.1016/j.dyepig.2020.108860

[7] Chang C, Hsieh M C, Lin J C, et al. Selective photodynamic therapy based on aggregation-induced emission enhancement of fluorescent organic nanoparticles[J]. Biomaterials, 2012, 33(3):897-906.

DOI: 10.1016/j.biomaterials.2011.10.018

[8] Zhuang J, Yang H, Li Y, et al. Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy[J]. Chemical Communications, 2020, 56(17):2630-2633.

DOI: 10.1039/d0cc00394h

[9] Wang Y , Xu D , Gao H , et al. Mechanofluorochromic properties of aggregation-induced emission-active tetraphenylethene-containing cruciform luminophores[J]. Dyes & Pigments, 2018: S0143720817326207.

DOI: 10.1016/j.dyepig.2018.04.021

[10] Benov, Ludmil. Photodynamic therapy: current status and future directions. [J]. Med Princ Pract, 2015, 24(s1):14-28.

DOI: 10.1159/000362416

[11] Hu F, Yuan Y, D Mao, et al. Smart activatable and traceable dual-prodrug for image-guided combination photodynamic and chemo-therapy[J]. Biomaterials, 2017, 144:53-59.

DOI: 10.1016/j.biomaterials.2017.08.018

[12] Leung C, Wang Z, Zhao E, et al. A Lysosome-Targeting AIEgen for Autophagy Visualization[J]. Advanced Healthcare Materials, 2016, 5(4):427-431.

[13] Wang J, Zhang W, Wu T, et al. Photodynamic antitumor activity of aggregation-induced emission luminogens as chemosensitizers for paclitaxel by concurrent induction of apoptosis and autophagic cell death[J]. Materials Chemistry Frontiers.

DOI: 10.1039/d1qm00089f

[14] X Cai, Liu B. Aggregation-Induced Emission: Recent Advances in Materials and Biomedical Applications[J]. Angewandte Chemie International Edition, (2020).

[15] Guillermo Moreno-Alcantara, Alibrandi A, Cola L D. Aggregation-Induced Emission in Electrochemiluminescence: Advances and Perspectives[J]. Topics in Current Chemistry, 2021, 379(4).

DOI: 10.1007/s41061-021-00343-9

[16] Dler E, Frster. Der Konzentrationsumschlag der Fluoreszenz des Pyrens[J]. Ztschrift für Physikalische Chemie, 1962, 31(1_4):274-277.

DOI: 10.1524/zpch.1962.34.1_4.132

[17] Meng G, Tang B Z. Fluorescent Sensors Based on Aggregation-Induced Emission: Recent Advances and Perspectives[J]. ACS Sensors, 2017, 2(10).

DOI: 10.1021/acssensors.7b00551

[18] Terai T, Nagano T. Small-molecule fluorophores and fluorescent probes for bioimaging[J]. Pflügers Archiv - European Journal of Physiology, 2013, 465(3):347-359.

DOI: 10.1007/s00424-013-1234-z

[19] Sample V, Newman R H, Zhang J. The structure and function of fluorescent proteins[J]. Chemical Society Reviews, 2009, 38(10):2852-2864.

[20] Kwok R, Leung C, Lam J, et al. Biosensing by luminogens with aggregation-induced emission characteristics[J]. Chemical Society Reviews, 2015, 44.

DOI: 10.1039/c4cs00325j

[21] Zhu C, Kwok R, Lam J, et al. Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine[J]. Acs Applied Bio Materials, (2018).

DOI: 10.1021/acsabm.8b00600

[22] Feng G, Liu B. Multifunctional AIEgens for Future Theranostics[J]. Small, 2016, 12(47).

[23] Miaomiao, Zhijun, Wenhan, et al. Good Steel Used in the Blade: Well-Tailored Type-l Photosensitizers with Aggregation-induced Emission Characteristics for Precise Nuclear Targeting Photodynamic Therapy. [J]. Wiley Online Library, (2021).

DOI: 10.1002/advs.202100524