Crystallographic Approach to Regenerated and Pathological Hard Tissues

Abstract:

A dominant inorganic substance in hard tissue is known to be a biological apatite (BAp)^nano-crystal which basically crystallizes in an anisotropic hcp lattice, and the BAp c-axis is parallel to extended collagen fibrils. We applied the microbeam X-ray diffractometer system with an incident beam spot 100µm or 50µm in diameter to the original, regenerated and pathological hard tissues in order to analyze the preferential alignment of the BAp c-axis as a parameter of bone quality closely relating to the mechanical function. We conclude that the BAp orientational distribution in the hard tissues is a new measure to evaluate stress distribution in vivo, nano-scale microstructure and the related mechanical function, healing process of the regenerated bone and progress of the bone diseases.

• Periodical: Materials Science Forum (Volume 512)
• Pages: 255-260
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.512.255
• Online since: April 2006
• Authors: Takayoshi Nakano, Takuya Ishimoto, Jee Wook Lee, Yukichi Umakoshi, Masaya Yamamoto, Yasuhiko Tabata, Akio Kobayashi, Hiroyoshi Iwaki, Kunio Takaoka, Mariko Kawai, Toshio Yamamoto
• Keywords: Biological Apatite (BAp), Bone, Bone Regeneration, Crystal Orientation, Microbeam X-Ray Diffraction (XRD), Osteoarthritis, Osteopetrosis, Osteoporosis, Pathological Hard Tissue, rBMP-2, Tissue Engineering

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