Effects of Exercise on Antitumor Efficacy of DHAQ-Loaded PLA-PLL-RGD Nanoparticles in Hepatocellular Carcinoma
This study mainly describes the synthesis of Arginine-Glycine-Aspartic (RGD) peptide modification of copolymer: poly(lactic acid-co-L-lysine) (PLA-PLL- RGD) and preparation of mitoxantrone(DHAQ)-loaded PLA-PLL-RGD nanoparticles (DHAQ-NP), and researches the effects of exercise on antitumor efficacy of DHAQ-NP in hepatocellular carcinoma. Experimental results show that compared with DHAQ-only group, the DHAQ concentration of tumor in Exercise+DHAQ-NP and DHAQ-NP groups up-regulate significantly. Tumor volume and weight of mice were significantly decreased in the DHAQ-NP and Exercise+DHAQ-NP groups as compared to with the Control group. Suggesting that DHAQ-NP can effectively inhibit the growth of hepatocellular carcinoma. Compared with DHAQ-NP group, the DHAQ concentration, tumor volume of Exercise+DHAQ-NP group have no significant changes. This suggests exercise can not significantly influence the antitumor efficacy of DHAQ-NP. These studies are essential to fully understand the safety and application of exercise as a supportive intervention in targeted therapies.
Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
P. F. Liu et al., "Effects of Exercise on Antitumor Efficacy of DHAQ-Loaded PLA-PLL-RGD Nanoparticles in Hepatocellular Carcinoma", Materials Science Forum, Vols. 610-613, pp. 1244-1247, 2009