Effects of Exercise on Antitumor Efficacy of DHAQ-Loaded PLA-PLL-RGD Nanoparticles in Hepatocellular Carcinoma

Abstract:

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This study mainly describes the synthesis of Arginine-Glycine-Aspartic (RGD) peptide modification of copolymer: poly(lactic acid-co-L-lysine) (PLA-PLL- RGD) and preparation of mitoxantrone(DHAQ)-loaded PLA-PLL-RGD nanoparticles (DHAQ-NP), and researches the effects of exercise on antitumor efficacy of DHAQ-NP in hepatocellular carcinoma. Experimental results show that compared with DHAQ-only group, the DHAQ concentration of tumor in Exercise+DHAQ-NP and DHAQ-NP groups up-regulate significantly. Tumor volume and weight of mice were significantly decreased in the DHAQ-NP and Exercise+DHAQ-NP groups as compared to with the Control group. Suggesting that DHAQ-NP can effectively inhibit the growth of hepatocellular carcinoma. Compared with DHAQ-NP group, the DHAQ concentration, tumor volume of Exercise+DHAQ-NP group have no significant changes. This suggests exercise can not significantly influence the antitumor efficacy of DHAQ-NP. These studies are essential to fully understand the safety and application of exercise as a supportive intervention in targeted therapies.

Info:

Periodical:

Materials Science Forum (Volumes 610-613)

Main Theme:

Edited by:

Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou

Pages:

1244-1247

DOI:

10.4028/www.scientific.net/MSF.610-613.1244

Citation:

P. F. Liu et al., "Effects of Exercise on Antitumor Efficacy of DHAQ-Loaded PLA-PLL-RGD Nanoparticles in Hepatocellular Carcinoma", Materials Science Forum, Vols. 610-613, pp. 1244-1247, 2009

Online since:

January 2009

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$35.00

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