Designing Nano-Hydroxyapatite in the Polyelectrolyte Complex Macroporous Scaffold Based on Chitosan and Hyaluronic Acid
Owing to the unique characters of the hybrid scaffold components, a novel biodegradable porous composite scaffold was prepared. The nano hydroxyapatite (HAP) (73~136 nm) was crystallized in situ on the organic polyelectrolyte complex matrix through a biomimetic method. The polyelectrolyte complex composed of chitosan and hyaluronic acid had strong impacts on the formation of the nano HAP and directed in situ crystallization of the nano HAP as template. The in situ nano HAP reduced the interfacial energy and presented nano intensifier to the nano hybrid scaffold. Meanwhile, the scaffold kept high porosity.
Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
J. D. Chen et al., "Designing Nano-Hydroxyapatite in the Polyelectrolyte Complex Macroporous Scaffold Based on Chitosan and Hyaluronic Acid", Materials Science Forum, Vols. 610-613, pp. 1252-1254, 2009