Study of Electrospun PLLACL Nanofibrous Mats for Drug Delivery System

Shui Ping Liu; Xiao Qiang Li; Yan Su; Lian Jiang Tan; Yu Zhang; Yan Mo Chen

doi:10.4028/www.scientific.net/MSF.610-613.1319

Paper Titles

Effects of bFGF and Collagen on the Construction of Tissue Engineering Cartilage In Vitro in the 3-D Culture System
p.1302

Effect of C₂H₂ Flow Rate on the Deposition of Zr-ZrC-ZrC/DLC Gradient Nano-Composite Film on Biomedical NiTi Alloy
p.1308

Study on Polylactide/Poly(ether block amide) Composite Biomaterials and Shape-Memory Effect
p.1312

The Segregation of Chemical Composition in NiTi Shape Memory Alloy Melted by VIM in Lime Crucible
p.1315

Study of Electrospun PLLACL Nanofibrous Mats for Drug Delivery System
p.1319

The Effects of Surfactants on the Granularity of the HA Powder Synthesized by Mechanochemistry
p.1323

Development and Properties of a New Correction Instrument of Pectus Excavatum
p.1327

Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release
p.1331

Osteogenesis of Porous Bioceramics Scaffolds Consisted of Hydroxyapatite Spherules after Implanted in Different Non-Osseous Sites
p.1335

HomeMaterials Science ForumMaterials Science Forum Vols. 610-613Study of Electrospun PLLACL Nanofibrous Mats for...

Study of Electrospun PLLACL Nanofibrous Mats for Drug Delivery System

Abstract:

In the present study an innovative tissue engineering scaffold was developed which can be used on wound dressing with a controllable drug-releasing capability. By coaxial electrospinning a coaxial nanofibrous mats were obtained which was made from Poly(L-lactid-co-ε-caprolactone) (PLLACL) and Tetracycline Hydrochloride (TCH), with P(LLA-CL) as the shell and TCH as the core. The TCH release behavior of the coaxial nanofibrous mats was measured by ultraviolet-visible (UV-vis) spectroscopy in vitro environment of 37°C for a maximum 180 hours. To compare with the method of mix electrospinning, TCH without any other material could encapsulated in P(LLA-CL) nanofibers very well and released for a long time.