Study of Electrospun PLLACL Nanofibrous Mats for Drug Delivery System

Abstract:

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In the present study an innovative tissue engineering scaffold was developed which can be used on wound dressing with a controllable drug-releasing capability. By coaxial electrospinning a coaxial nanofibrous mats were obtained which was made from Poly(L-lactid-co-ε-caprolactone) (PLLACL) and Tetracycline Hydrochloride (TCH), with P(LLA-CL) as the shell and TCH as the core. The TCH release behavior of the coaxial nanofibrous mats was measured by ultraviolet-visible (UV-vis) spectroscopy in vitro environment of 37°C for a maximum 180 hours. To compare with the method of mix electrospinning, TCH without any other material could encapsulated in P(LLA-CL) nanofibers very well and released for a long time.

Info:

Periodical:

Materials Science Forum (Volumes 610-613)

Main Theme:

Edited by:

Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou

Pages:

1319-1322

DOI:

10.4028/www.scientific.net/MSF.610-613.1319

Citation:

S. P. Liu et al., "Study of Electrospun PLLACL Nanofibrous Mats for Drug Delivery System", Materials Science Forum, Vols. 610-613, pp. 1319-1322, 2009

Online since:

January 2009

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$35.00

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