In Vitro Assessment of Antibacterial Activity and Cytotoxicity of Silver Contained Antibacterial HA Coating Material

Abstract:

Failure of dental implant is often caused by specific pathogenic bacteria. In this paper, antibacterial HA coating was prepared by vacuum plasma spraying with silver loaded zirconium phosphate containing HA as feedstock. The antibacterial activity against Aa，Fn and Pg was evaluated using a film covering method. MTT colorimetric assay was used to measure cytotoxic effect of the antibacterial HA coatings. Results show that the HA coatings displayed significant antibacterial activity against Aa，Fn, Pg and no cytotoxicity to L929 murine cell lines when the content of silver-loaded zirconium phosphate antimicrobial is between 5wt% to 10wt%. The sensitivity of the bacteria to the antibacterial HA coating is in sequence of Pg >Fn >Aa.

• Periodical: Materials Science Forum (Volumes 620-622)
• Pages: 307-310
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.620-622.307
• Online since: April 2009
• Authors: Zi Yuan Zhu, Fu Qiang Zhang, You Tao Xie, Yi Kai Chen, Xue Bin Zheng
• Keywords: Antibacterial Activity, Cytotoxicity, HA Coating, Implant, Silver-Loaded Zirconium Phosphate

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