Simultaneous Incorporation of 5-Fluorouracil and Leucovorin into Chitosan Nanoparticle as Drug Carrier and Its Characterization

Pu Wang Li; Yi Chao Wang; Zheng Peng; Ling Xue Kong

doi:10.4028/www.scientific.net/MSF.654-656.2265

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A Study of a Retention of Antimicrobial Activity by Plasma Polymerized Terpinen-4-ol Thin Films
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Simultaneous Incorporation of 5-Fluorouracil and Leucovorin into Chitosan Nanoparticle as Drug Carrier and Its Characterization
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HomeMaterials Science ForumMaterials Science Forum Vols. 654-656Simultaneous Incorporation of 5-Fluorouracil and...

Simultaneous Incorporation of 5-Fluorouracil and Leucovorin into Chitosan Nanoparticle as Drug Carrier and Its Characterization

Abstract:

A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.

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Materials Science Forum (Volumes 654-656)

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2265-2268

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.654-656.2265

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Online since:

June 2010

Authors:

Pu Wang Li, Yi Chao Wang, Zheng Peng, Ling Xue Kong

Keywords:

5-Fluorouracil, Chitosan Nanoparticle, Colorectal Cancer, Combined Therapy, Leucovorin

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