A Novel Biodegradable Multichamber Microstructure for Implantable Drug Controlled Release
The research work reported in this paper design a novel biodegradable multichamber microstructure for implantable drug controlled release by introducing the approach of topology optimization. It is therefore highly desirable to overcome these restrictions that pre-defined topology of the device result in difficulty to obtain a linear or pulsed drug release profile. The designed biodegradable multichamber microstructure is fabricated using UV-LIGA microfabrication and Micro-molding technique. The simulation results show that the multichamber microstructure exhibits a preferable linear drug release profile.
Jian-Feng Nie and Allan Morton
R. X. Yu et al., "A Novel Biodegradable Multichamber Microstructure for Implantable Drug Controlled Release", Materials Science Forum, Vols. 654-656, pp. 2269-2272, 2010