A Novel Biodegradable Multichamber Microstructure for Implantable Drug Controlled Release

Rui Xia Yu; Xiang Yang Zhou; Zeng Zhao

doi:10.4028/www.scientific.net/MSF.654-656.2269

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HomeMaterials Science ForumMaterials Science Forum Vols. 654-656A Novel Biodegradable Multichamber Microstructure...

A Novel Biodegradable Multichamber Microstructure for Implantable Drug Controlled Release

Abstract:

The research work reported in this paper design a novel biodegradable multichamber microstructure for implantable drug controlled release by introducing the approach of topology optimization. It is therefore highly desirable to overcome these restrictions that pre-defined topology of the device result in difficulty to obtain a linear or pulsed drug release profile. The designed biodegradable multichamber microstructure is fabricated using UV-LIGA microfabrication and Micro-molding technique. The simulation results show that the multichamber microstructure exhibits a preferable linear drug release profile.

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Periodical:

Materials Science Forum (Volumes 654-656)

Pages:

2269-2272

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.654-656.2269

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Online since:

June 2010

Authors:

Rui Xia Yu, Xiang Yang Zhou, Zeng Zhao

Keywords:

Biodegradable Polymer, Drug Controlled Release, Topological Optimisation, UV-LIGA

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References

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