Degradation Experiments and Modeling of PLGA Blend and Gradient Films

Hong Ze Liu; Min Qi; Xing Hua Zhu; Zhi Yong Wei

doi:10.4028/www.scientific.net/MSF.685.331

Paper Titles

The Influence of the Purity of Gd on the Magnetocaloric Effect in Gd₅Si_2-XGe_2-XZn_2x Alloys
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The Performance Study of Aviation Fuel Added with Alcohols
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Biosynthesis of Carboxymethylated Bacterial Cellulose Composite for Wound Dressing
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Biotribology Behavior of Ultra-High Molecular Weight Polyethylene against Carbon/Carbon Composites Used for Hip Joint Replacement
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Degradation Experiments and Modeling of PLGA Blend and Gradient Films
p.331

Effect of Hydroxyapatite Matrix on the Growth of Carbon Nanotubes via a CVD System
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High Temperature Stability of SiC/Ti Interface
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Inhibition of Taq DNA Polymerase and DNA Exonuclease ExoIII by an Aqueous Nanoparticle Suspension of a Bis-Methanophosphonate Fullerene
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Inhibitory Effect of Hydroxyapatite Nanoparticles on K562 Cells
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HomeMaterials Science ForumMaterials Science Forum Vol. 685Degradation Experiments and Modeling of PLGA Blend...

Degradation Experiments and Modeling of PLGA Blend and Gradient Films

Abstract:

PLGA blend and gradient films were designed and prepared to improve the late degradation properties of PLGA films. The gradient films were composed of gradual components of PLGA50/50 and PLGA 75/25, and PLGA 50/50, featuring gradual descents from outside parts to inside parts of the films. Degradation processes of biodegradable PLGA blend and gradient films were also predicted by Monte Carlo simulation to understand the mechanism of degradation. The simulation results indicated that the gradient structure prolonged the mass transfer time of the degradable films, and it induced smoother weight loss than single-component or blend films. The degradation behaviors of single-component, blend and gradient films were experimentally investigated to prove the validity of the models by immersing them into PBS. The experiment indicated that the gradient films have the most stable weight loss curves, which were in well accordance with the simulation by Monte Carlo method.