Tetracycline Double Labelling Tracing Investigation for In Vivo Osteogenetic Course of PDLLA/HA Composite

Xin Yu Wang; Xue Zhi Shan; Yin Chao Han; Shi Pu Li

doi:10.4028/www.scientific.net/MSF.685.394

Paper Titles

Inhibitory Effect of Hydroxyapatite Nanoparticles on K562 Cells
p.352

Mechanical Properties and Microstructure of Short Carbon Fiber Reinforced Hydroxyapatite Bio-Composite
p.357

Modification of Pearl Surface Microstructure by Rare Earth Cerium Induced Growing
p.362

Preparation and Characterization of Zn-Containing Hydroxyapatite/TiO₂ Composite Coatings on Ti Alloys
p.367

Strontium-Borosilicate-Co-Effects to Stimulate Bone Regeneration
p.371

Mechanism of High Fracture Strength of Bone
p.379

Study on the Cytotoxicity In Vitro of Composite Materials Based on Poly(L-Lactide-Co-Glycolide) and Bioactive Glass
p.384

Synthesis, Microstructure and Properties of Poly(L-Lactic Acid-Co-α-Alanine) Obtained by Direct Melting Copolymerization
p.390

Tetracycline Double Labelling Tracing Investigation for In Vivo Osteogenetic Course of PDLLA/HA Composite
p.394

HomeMaterials Science ForumMaterials Science Forum Vol. 685Tetracycline Double Labelling Tracing...

Tetracycline Double Labelling Tracing Investigation for In Vivo Osteogenetic Course of PDLLA/HA Composite

Abstract:

The PDLLA(DL-Poly lactic acids)/HA(Hydroxyapatite) composite and pure PDLLA control were implanted in bone for test. Using fluorescent pictures of tetracycline double label and advanced image analysis system, the trend of bone-formation rate for the implanting region of PDLLA/HA composite was obtained via morphometry measurement of the slices labeled with tetracycline. The investigation and calculation results show that, the formation rate of new bone is stable and high (reaches 2.044μm/day) in the early stage of implantation for the PDLLA/HA composite, demonstrating the advantageous capability of bone formation for the composite. The formation rate of new bone seems to decrease continuously with time, and then the bone formation and bone decomposition tend towards equilibration. Namely, the dynamic balance of bony tissue’s metabolism is maintained.

You might also be interested in these eBooks

Energy, Environment and Biological Materials

View Preview

Info:

Periodical:

Materials Science Forum (Volume 685)

Pages:

394-398

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.685.394

Citation:

Cite this paper

Online since:

June 2011

Authors:

Xin Yu Wang, Xue Zhi Shan, Yin Chao Han, Shi Pu Li

Keywords:

Biodegradation, Osteogenetic Rate, PDLLA/HA Composite, Tracing

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] A.M. Parffit, M.K. Drezner, F.X. Glorieux, et al.: J BoneMiner Res Vol. 17 (1987), pp.137-146.

Google Scholar

[2] G.F. Draenert and M. Delius: Biomaterials Vol. 28(8) (2007), pp.1531-1538.

Google Scholar

[3] M. R. Sarkar, P. Augat, S. J. Shefelbine, et al.: Biomaterials Vol. 27(9) (2006), pp.1817-1823.

Google Scholar

[4] M. Wieland , M. Textor , B. Chehroudi , et al.: Biomaterials Vol. 26(10) (2005), pp.1119-1130.

Google Scholar

[5] M. A. W. Merkx, J. C. Maltha, H. M. Freihofer: Biomaterials Vol. 20(21) (1999), p.2029-(2035).

DOI: 10.1016/s0142-9612(99)00105-2

Google Scholar

[6] M. Lamghari, H. Huet, A. Laurent, et al.: Biomaterials Vol. 20(22) (1999), pp.2107-2114.

Google Scholar

[7] K. Matsuzaka, X. F. Walboomers, J. E. de Ruijter, et al.: Biomaterials Vol. 20(14) (1999), pp.1293-1301.

Google Scholar

[8] F. H. Lin, C. C. Lin, C. M. Lu, et al.: Biomaterials Vol. 16(10) (1995), pp.793-802.

Google Scholar

[9] F. H. Lin, C. C. Lin, H. C. Liu, et al.: Biomaterials Vol. 15(13) (1994), pp.1087-1098.

Google Scholar

[10] C. P.A.T. Klein, P. Patka and W. den Hollander: Biomaterials Vol. 10(1) (1989), pp.59-62.

Google Scholar

[11] U. Joos and G. Ochs: Biomaterials Vol. 1(1) (1980), pp.23-26.

Google Scholar