Synthesis, Microstructure and Properties of Poly(L-Lactic Acid-Co-α-Alanine) Obtained by Direct Melting Copolymerization

Lian Liu; Xie Wei Chen; Pei Wang; Zhi Yong Wei; Chun Yun Liu; Min Qi

doi:10.4028/www.scientific.net/MSF.685.390

Paper Titles

Inhibitory Effect of Hydroxyapatite Nanoparticles on K562 Cells
p.352

Mechanical Properties and Microstructure of Short Carbon Fiber Reinforced Hydroxyapatite Bio-Composite
p.357

Modification of Pearl Surface Microstructure by Rare Earth Cerium Induced Growing
p.362

Preparation and Characterization of Zn-Containing Hydroxyapatite/TiO₂ Composite Coatings on Ti Alloys
p.367

Strontium-Borosilicate-Co-Effects to Stimulate Bone Regeneration
p.371

Mechanism of High Fracture Strength of Bone
p.379

Study on the Cytotoxicity In Vitro of Composite Materials Based on Poly(L-Lactide-Co-Glycolide) and Bioactive Glass
p.384

Synthesis, Microstructure and Properties of Poly(L-Lactic Acid-Co-α-Alanine) Obtained by Direct Melting Copolymerization
p.390

Tetracycline Double Labelling Tracing Investigation for In Vivo Osteogenetic Course of PDLLA/HA Composite
p.394

HomeMaterials Science ForumMaterials Science Forum Vol. 685Synthesis, Microstructure and Properties of...

Synthesis, Microstructure and Properties of Poly(L-Lactic Acid-Co-α-Alanine) Obtained by Direct Melting Copolymerization

Abstract:

A new poly(ester amide)s (PEA) derived from L-lactic acid and α-alanine have been synthesized by melting copolymerization with p-toluenesulfonic acid (TSA) with stannous chloride (SnCl₂) as catalyst. The products were analyzed by NMR, FT IR techniques. The effects of the content of α-alanine (L-Ala) on the copolymers structure were studied. Being the phosphate buffered saline (pH=7.2) as the degradation solution, the degradation rate speed up with the increasing the content of the α-alanine.

You might also be interested in these eBooks

Energy, Environment and Biological Materials

View Preview

Info:

Periodical:

Materials Science Forum (Volume 685)

Pages:

390-393

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.685.390

Citation:

Cite this paper

Online since:

June 2011

Authors:

Lian Liu, Xie Wei Chen, Pei Wang, Zhi Yong Wei, Chun Yun Liu, Min Qi

Keywords:

Alanine, Biodegradable, Melting Copolymerization, Polyester Amidea, Polylactide (PLA)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] A. K. Salem, S. M. Cannizzaro, M. C. Davies, S. J. B. Tendler, C. J. Roberts, P. M. Williams and K.M. Shakesheff: Biomacromolecules Vol. 2 (2001), p.575.

Google Scholar

[2] A. A. Deschamps, A. A. van Apeldoorn, J. D. de Bruijn, D. W. Grijpma and J. Feijen: Biomaterials Vol. 24 (2003), P. 2643.

Google Scholar

[3] Y. J. Fan, M. Kobayashi and H. Kise: Polym. J. Vol. 32 (2000), p.817.

Google Scholar

[4] K. Guo, C. C. Chu, E. Chkhaidze and R. Katsarava: J. Polym. Sci., Part A: Polym. Chem. Vol. 43 (2005), p.1463.

Google Scholar

[5] R. Smith: Biodegradable Polymers for Industrial Applications (Woodhead Publishing, Cambridge, 2005).

Google Scholar

[6] M. Sokolsky-Papkov, K. Agashi, A. Olaye, K. Shakesheff, and A.J. Domb: Adv. Drug Deliv. Rev. Vol. 59 (2007), p.187.

DOI: 10.1016/j.addr.2007.04.001

Google Scholar

[7] R.A. Miller, J.M. Brady and D.E. Cutright: J. Biomed. Mater. Res. Vol. 11 (1977), p.711.

Google Scholar

[8] H. Tsuji, T. Ishida and N. Fukuda: Polym. Int. Vol. 52(2003), p.843.

Google Scholar

[9] Y. Tian, C. Zhou, Q. Zeng, J. Yang, F. Han and J. Tian: Appl. Surf. Sci. Vol. 255 (2008), p.446.

Google Scholar