Study on the Cytotoxicity In Vitro of Composite Materials Based on Poly(L-Lactide-Co-Glycolide) and Bioactive Glass

Abstract:

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The effect of poly(L-lactide-co-glycolide)/bioactive glass (PLGA/BG) on cell attachment, proliferation and differentiation of L929 fibroblastic cells was investigated. The results of in-vitro cytotoxicity test indicated that the cells cultured in extract of PLGA/BG and on the surface of composite showed normal growth and proliferation. The cell proliferation and alkaline phosphatase (ALP) activity of fibroblast were significantly improved after 3 and 7 days of culture on PLGA/BG films in comparison with PLGA films. It can be concluded that the addition of bioactive glass into PLGA stimulates the proliferation and differentiation of fibroblastic cells. Therefore, PLGA/BG composites have a promising biological response as a potential biomaterial in medical field.

Info:

Periodical:

Edited by:

Kunyuan Gao, Shaoxiong Zhou, Xinqing Zhao

Pages:

384-389

DOI:

10.4028/www.scientific.net/MSF.685.384

Citation:

Z. H. Zhou et al., "Study on the Cytotoxicity In Vitro of Composite Materials Based on Poly(L-Lactide-Co-Glycolide) and Bioactive Glass", Materials Science Forum, Vol. 685, pp. 384-389, 2011

Online since:

June 2011

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$35.00

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