Study on the Cytotoxicity In Vitro of Composite Materials Based on Poly(L-Lactide-Co-Glycolide) and Bioactive Glass

Abstract:

The effect of poly(L-lactide-co-glycolide)/bioactive glass (PLGA/BG) on cell attachment, proliferation and differentiation of L929 fibroblastic cells was investigated. The results of in-vitro cytotoxicity test indicated that the cells cultured in extract of PLGA/BG and on the surface of composite showed normal growth and proliferation. The cell proliferation and alkaline phosphatase (ALP) activity of fibroblast were significantly improved after 3 and 7 days of culture on PLGA/BG films in comparison with PLGA films. It can be concluded that the addition of bioactive glass into PLGA stimulates the proliferation and differentiation of fibroblastic cells. Therefore, PLGA/BG composites have a promising biological response as a potential biomaterial in medical field.

• Periodical: Materials Science Forum (Volume 685)
• Pages: 384-389
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.685.384
• Online since: June 2011
• Authors: Zhi Hua Zhou, Yong Yi Gao, Qing Feng Yi, Qing Quan Liu, Li Hua Liu
• Keywords: Bioactive Glass, Cytotoxicity, In Vitro, Poly(lactide-co-glycolide)

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