In this paper, a series of experiments were carried out on normal and high speed milling of a new damage-tolerant titanium alloy. The effects of milling parameters on cutting force and cutting temperature were investigated. The tool life of three commonly used cutters, such as WK10, WMG40 and WXN15, were studied. Result shows that the tool life of cutter WXN15 was the longest one when using the same flank wear VB as a standard, and cutter WK10 had a longer too life than cutter WMG40. Thus cutter WXN15 was the most suitable cutting tool to machining TC4-DT, and cutter WK10 was better than cutter WMG40.