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The Influence of the PCL-T Concentration in PLDLA Membrane

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Abstract:

The use of bioabsorbable polymers in biomedical application has increased greatly in recent years due to their good compatibility and bio-reabsorption. To obtain a polymeric material suitable for medical applications, the obtention and characterization of copolymer poly (L-co-DL lactic acid) (PLDLA) with the addition of poly (caprolactone triol) (PCL-T) was studied. PLDLA/PCL-T membranes were prepared by solvent casting in the 100/0, 90/10 and 70/30 (w/w) compositions. The membranes were characterized by Atomic Force Microscopy (AFM), Cellular Adhesion and Energy Dispersed Spectroscopy (EDS). Using MFA it was observed that an addition of PCL-T contributes to rough morphology and greater porosity. Increased cell adhesion on 90/10 and 70/30 membranes compared to 100/0 composition and controls was observed. From these results, it was observed that PCL-T improved cellular adhesion of the PLDLA membrane when compared to membranes without PCL-T. The PLDLA/PCL-T membrane is indicated for use in medical devices which do not require long implantation time, such as support for cell culture, dressings for skin ulceration and guided regeneration in periodontics.

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Advanced Materials Forum VI View Preview

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Periodical:

Materials Science Forum (Volumes 730-732)

Pages:

50-55

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.730-732.50

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Online since:

November 2012

Authors:

Marcia Adriana Tomaz Duarte, Larissa Coppini, C. Lucchesi, Marcelo Macedo, Eliana Aparecida De Rezende Duek

Keywords:

Biomaterial, PCL-T, Plasticizer

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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