Electrochemical Impedance Spectroscopy: Evaluation of Drug Delivery System of Alpha-Tricalcium Phosphate Cement

Abstract:

Tricalcium phosphate cement (α-TCP) can be used in various fields of health, including as drug delivery systems. The application of a biomaterial based on α-TCP could enable both the constant drug delivery as support and shape damaged muscleskeletics tissues until which can be regenerated by the organism itself, replacing the biomaterial, while maintaining stable levels of the drug in the organism. The aim of this study was to evaluate the release of gentamicin sulfate using the technique of electrochemical impedance spectroscopy in drug delivery systems of α-TCP. The results obtained in vitro study validated the proposed methodology for assessment of controlled drug delivery systems on the basis of α-TCP.

• Periodical: Materials Science Forum (Volume 820)
• Pages: 293-296
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.820.293
• Online since: June 2015
• Authors: Julio Cesar Colpo*, Caroline Pigatto, Camila F. Escobar, Tiago Delbrücke, Jose R. Jurado, Vânia Caldas Sousa, Luis Alberto Santos
• Keywords: Alpha-Tricalcium Phosphate Cement, Bioceramic, Biomaterial, Eletrochemical Impedance Spectroscopy, Gentamicin Sulfate

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