Evaluation of the Cytotoxicity of NiFe2O4/SiO2 Hybrid Nanoparticles Aiming its Application as Drug Carriers

Elvia Leal; Joelda Dantas; Patrícia Tatiana de Araújo Santos; Sheyla Maria de Castro Máximo Bicalho; Dámiana Máximo Brandão; A.C.F. de M. Costa

doi:10.4028/www.scientific.net/MSF.820.303

Paper Titles

The Influence of Dopants in the Grain Size of Alumina - A Review
p.280

Effect of Sonochemical Technique on the Morphology and Crystallinity of Hydroxyapatite Nanoparticles
p.287

Electrochemical Impedance Spectroscopy: Evaluation of Drug Delivery System of Alpha-Tricalcium Phosphate Cement
p.293

Aging Behavior of Commercial and Synthesized Dental Y-TZP Ceramics
p.297

Evaluation of the Cytotoxicity of NiFe₂O₄/SiO₂ Hybrid Nanoparticles Aiming its Application as Drug Carriers
p.303

Production of Hydroxyapatite/Polyhydroxibutirate Based Composites for Biomaterials Applications
p.309

Evaluation of Morphology and Roughness of the Surface of a Ceramic Based on Lithium Disilicate, after Conditioning with Acid Hydrofluoric the 5% and 10%
p.315

Evaluation of Mechanical Properties of Composite Materials Used in Dentistry Varying the Inorganic Composition
p.320

Analysis of Flexural Strength of Ceramics Based on Zirconia Stabilized by Yttria with Ceramic Cover
p.325

HomeMaterials Science ForumMaterials Science Forum Vol. 820Evaluation of the Cytotoxicity of NiFe2O4/SiO2...

Evaluation of the Cytotoxicity of NiFe₂O₄/SiO₂ Hybrid Nanoparticles Aiming its Application as Drug Carriers

Abstract:

Magnetic nanoparticles have potential application in biomedicine since their features allow a wide variety of applications, such as drug carriers, destruction of tumor cells and magnetic separation of cells and proteins. Overlooking that, the proposal is to obtain the hybrid NiFe₂O₄/SiO₂ from the surface modifying with the 3-aminopropyltriethoxysilane, and evaluate the structure, morphology and cytotoxicity, to obtain a biocompatible hybrid for biological applications, such as, e.g., drug carrier. The samples were analyzed by XRD, FTIR, SEM, magnetic measurements and cytotoxicity. The results showed the formation of single phase of the NiFe₂O₄ spinel with crystallite size of 35 and 32 nm referring to the samples before and after the surface modification, and presence of characteristic absorption bands of the spinel and of the silanol group from the silane agent, confirming the hybrid formation. The presence of the silane agent kept the ferrimagnetic characteristic and increased the cell viability, making it a non-cytotoxic material.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Materials Science Forum (Volume 820)

Pages:

303-308

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.820.303

Citation:

Cite this paper

Online since:

June 2015

Authors:

Elvia Leal, Joelda Dantas, Patrícia Tatiana de Araújo Santos, Sheyla Maria de Castro Máximo Bicalho, Dámiana Máximo Brandão, A.C.F. de M. Costa

Keywords:

Biomaterial, Cytotoxicity, Magnetic Nanoparticles, NiFe₂O₄, Silane Agent

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] G. Reiss, A. Hutten: Nat. Mater. Vol. 10 (2005), p.725.

Google Scholar

[2] H. Zhu, J. Tao, W. Wang, Y. Zhou, P. Li, Z. Li, K. Yan, S. Wu, K.W.K. Yeung, Z. Xu, H. Xu, P.K. Chu: Biomaterials Vol. 34 (9) (2013), p.2296.

Google Scholar

[3] A.A. Ensafi, A.R. Allafchian: Colloid. Surface B Vol. 102 (2013), p.687.

Google Scholar

[4] C.L. Tseng, K.C. Chang, M.C. Yeh, K.C. Yang, T.P. Tang, F.H. Lin: Ceram. Int. Vol. 40 (4) (2014), p.5117.

Google Scholar

[5] F. Ye, A. Barrefelt, H. Asem, M. Abedi-Valugerdi, I. El-Serafi, M. Saghafian, K. Abu-Salah, S. Alrokayan, M. Muhammed, M. Hassan: Biomaterials Vol. 35 (12) (2014), p.3885.

DOI: 10.1016/j.biomaterials.2014.01.041

Google Scholar

[6] M. Ziegler-Borowska, T. Siódmiak, D. Chełminiak, A. Cyganiuk, M.P. Marszałł: Appl. Surf. Sci. Vol. 288 (2014), p.641.

DOI: 10.1016/j.apsusc.2013.10.088

Google Scholar

[7] S. Mohapatra, S.R. Rout, A.B. Panda: Colloid. Surface A Vol. 384 (2011), p.453.

Google Scholar

[8] S. Maensiri, C. Masingboon, B. Banjong, S. Seraphin: Scripta Mater. Vol. 56 (2007), p.797.

Google Scholar

[9] F. Kurayama, S. Suzuki, T. Oyamada, T. Furusawa, M. Sato, N. Suzuki: J. Colloid Interf. Sci. Vol. 349 (2010), p.70.

Google Scholar

[10] S.R. Jain, K.C. Adiga, V.A. Pai Verneker: Combust. Flame Vol. 40 (1981), p.71.

Google Scholar

[11] P.T.A. Santos, P.T.A. Santos, P.M.A.G. Araújo, A.C.F.M. Costa: 7° Congresso Latino-Americano de Orgãos Artificiais e Biomateriais. Natal, 22-25 Agosto 2012. Procceding.. Natal 2012. (RN).

Google Scholar

[12] L.V. Azároff: Elements of X-ray crystallography. (McGraw-Hill Book Company, 1968).

Google Scholar

[13] I. Khosravi, M. Eftekhar: Powder Technol. Vol. 250 (2013), p.147.

Google Scholar

[14] M.R. Phadatare, A.B. Salunkhe, V.M. Khot, C.I. Sathish, D.S. Dhawale, S.H. Pawar: J. Alloy. Compd. Vol. 546 (2013), p.314.

Google Scholar

[15] M. Demirelli, E. Karaoglu, A. Baykal, H. Sözeri, E. Uysal: J. Alloy. Compd. Vol. 582 (2014), p.201.

Google Scholar

[16] A. Tomitaka, A. Hirukawa, T. Yamada, S. Morishita, Y. Takemura: J. Magn. Magn. Mater. Vol. 321 (10) (2009), p.1482.

Google Scholar