Determination of Gelation Kinetic Parameters for a Chitosan/β-Glycerophosphate Injectable Hydrogel by Means of Rheological Measurement

Abstract:

The aim of the current study was to improve the knowledge of the gelation process of injectable thermosensitive hydrogels comprising chitosan (CS) and β-glycerophosphate disodium salt (β-GP). The sol-gel transition process was precisely tracked by means of rheological measurement, in which the viscosity changed considerably with gelation time and temperature. The zero-order kinetics model was assumed to adequately describe the extent of gelation reaction. The reaction rate constant increased continuously with the increasing temperature and β-GP concentration. According to Arrhenius equation, the activation energies of gelation reaction for the chitosan injectable hydrogels were calculated as 64.38 KJ/mol, 101.68 KJ/mol and 140.92 KJ/mol for the samples containing 4% w/v, 6% w/v and 8% w/v of β-GP, respectively. It could be an effective way to study the gelation dynamics of injectable hydrogels, and provide references for clinical practice.

• Periodical: Materials Science Forum (Volume 848)
• Pages: 543-550
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.848.543
• Online since: March 2016
• Authors: Qian Qian Wang, Da Jun Chen
• Keywords: Dynamic, Gelation Process, Injectable Hydrogel, Rheological Measurement, Sol-Gel

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