Reduction-Degradable Shell Cross-Linked Micelle with pH-Responsive Cores Prepared via Click Chemistry

Abstract:

A well-defined poly [(ethylene glycol)-block-2-(dimethylamino) ethyl methacrylate-block-2-(diethylamino) methacrylate] (PEG-b-DMA-b-DEA) triblock copolymer was synthesized via atom transfer radical polymerization (ATRP) by successively polymerization of DMA and DEA monomers using a PEG-based macroinitiator, and obtained copolymer was then converted to be PEG-b-P(DMA-co-QDMA)-b-PDEA copolymer with “clickable” moieties in the middle block by the quaternization with propargyl bromide. Those copolymers prepared were characterized by proton Nuclear Magnetic Resonance (¹H NMR) and Gel Permeation Chromatography (GPC), and its self-assembly behavior and subsequently fixation with bis-(azidoethyl) disulfide via click chemistry resulting reduction-sensitive shell-cross-linked (SCL) micelle in purely aqueous solution were investigated by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS). The results show the micellar structure could be effectively cross-linked via click chemistry and also be dissociated at reduction condition, which may realize it's potential application as novel drug delivery carriers.

• Periodical: Materials Science Forum (Volume 848)
• Pages: 527-531
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.848.527
• Online since: March 2016
• Authors: Lu Bin Lin, Qing Yun Yu, Zhuo Qun Gu, Xiao Ze Jiang*, Mei Fang Zhu
• Keywords: 2-(Diethylamino) Methacrylate, 2-(Dimethylamino)Ethyl Methacrylate, Click Chemistry, pH-Responsive, Reduction-Degradable, Shell-Cross-Linked (SCL) Micelle

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