Preparation and Biological Properties of Nano-Silk Fibroin/Polyurethane/Silver Nanoparticles Composite Membranes

Abstract:

A series of the blending membranes comprised of the different mass ratio of silk fibroin peptide (SFP) power, silver nanoparticles (NanoAg) and polyurethane (PU) were prepared with mixing the SFP power, silver nitrate and PU, and the silver nitrate was reduced to NanoAg by SFP in this mixing process. UV spectrum was used to detect the nanoAg. The experimental results confirmed the formation of NanoAg. The dissolution of the obtained membranes in simulated body fluid (SBF) were determined, and showed that the membranes had good stability. Their mechanical properties were also determined. The results revealed that the mass ratio of SFP to PU was an important influence factor, and the mass ratio 30/70 (SFP/PU) of the membrane was the optimum. The Antibacterial properties against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were examined, the results of which indicated that the membranes containing NanoAg had a good bactericidal effect. The SFP/PU/NanoAg membranes also showed good cell and blood compatibility, and then they have application prospect as an antibacterial materials using for medical catheters.

• Periodical: Materials Science Forum (Volume 848)
• Pages: 557-566
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.848.557
• Online since: March 2016
• Authors: Jiang Feng Li, Zhong Min Chen, Qin Luo, Guang Hui Zhang, Fu Ping Wang
• Keywords: Antibacterial Activities, Mechanical Properties, Medical Catheters, Nano-Silk Fibroin, Silver Nanoparticles

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