Antibacterial Activity of a Chitosan Derivative Obtained in the Absence of a Solvent

Luizângela Reis Osório; Idglan Sá Lima; Humberto Medeiros Barreto; Josy Antoveli Osajima; Edson Cavalcanti da Silva Filho

doi:10.4028/www.scientific.net/MSF.869.869

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Antibacterial Activity of a Chitosan Derivative Obtained in the Absence of a Solvent

Abstract:

A novel chitosan derivative was prepared through direct reaction of pure chitosan with acetylacetone in the absence of a solvent, and it was characterized by elemental analysis, Fourier transform infrared spectrometry (FTIR), and ¹³C Nuclear Magnetic Ressonance (NMR) spectroscopy. Moreover, the antibacterial properties of the new biomaterial were tested by the direct contact method against multi-drug resistant strains of Staphylococcus aureus and Escherichia coli. The results from the characterization were consistent with the modification of the chemical structure made. The new derivative showed a better antibacterial activity than raw chitosan against E. coli strains, indicating that incorporation of imine link (Schiff base) enhanced its antibacterial activity against Gram-negative bacterium. On the contrary, this chemical change did not decrease its antibacterial activity against Gram-positive bacterium.