Development and Evaluation of Capsule of Sodium Diclofenac and Paracetamol Using Mesocarp Babassu Powder as Excipient - Part II

Ilka de Carvalho Barros; Lécia Maria da Silva Freire; José Lamartine Soares Sobrinho; Edson Cavalcanti da Silva Filho; Lívio César Cunha Nunes

doi:10.4028/www.scientific.net/MSF.869.849

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HomeMaterials Science ForumMaterials Science Forum Vol. 869Development and Evaluation of Capsule of Sodium...

Development and Evaluation of Capsule of Sodium Diclofenac and Paracetamol Using Mesocarp Babassu Powder as Excipient - Part II

Abstract:

The capsules are pharmaceutical forms extremely versatile used to administer drugs orally, thus demonstrating the relevance of search for new excipients. Therefore, it was aimed to demonstrate the technological feasibility of babassu mesocarp powder (MB) as an excipient in development of diclofenac capsules 50mg and paracetamol 500 mg. Two lots of capsule were produced for each active ingredient separately using MB and microcrystalline cellulose (MC) as an excipient. The analytical results of quality control of all lots remained within the limits accepted by the Brazilian Pharmacopoeia. Although the values of dissolution time coming from lots of CM and MB, the statistical analysis revealed that lots manufactured with MB showed a profile of release superior to CM, demonstrating the potential of MB as an excipient once the lots produced with MB showed a disintegration and dissolution equivalent to those obtained with CM lots.

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21st Brazilian Conference on Materials Science and Engineering

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Periodical:

Materials Science Forum (Volume 869)

Pages:

849-853

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.869.849

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Online since:

August 2016

Authors:

Ilka de Carvalho Barros*, Lécia Maria da Silva Freire, José Lamartine Soares Sobrinho, Edson Cavalcanti da Silva Filho, Lívio César Cunha Nunes

Keywords:

Babassu, Capsules, Dissolution, Excipients, Microcrystalline Cellulose (MC)

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