MgO Implanted in Rat Tibia Bone Marrow is Osteoinductive through the Formation of a Matrix, Containing Hydroxyapatite

Håkan Nygren; Per Malmberg; Yang  Liu

doi:10.4028/www.scientific.net/MSF.879.1404

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HomeMaterials Science ForumMaterials Science Forum Vol. 879MgO Implanted in Rat Tibia Bone Marrow is...

MgO Implanted in Rat Tibia Bone Marrow is Osteoinductive through the Formation of a Matrix, Containing Hydroxyapatite

Abstract:

Healing of rat tibia after intramedullary implantation of MgO was analysed by Environmental Scanning Electron Microscopy (ESEM) and Energy-Dispersive X-ray spectroscopy (EDX). The results indicated the formation of hydroxyl-apatite (HA) in the entire intramedullary space after 1 week of healing. Then, corroded Mg, MgO and MgCO₃ were incubated with DMEM in vitro for 24 h and the surface of the material was analysed by EDX and Time-of-Flight Secondary Ion Mass (ToF-SIMS). The chemical analysis of the Mg corrosion products indicate that HA is formed at the material surface and that MgCO₃ was an efficient catalyzer of HA formation

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Periodical:

Materials Science Forum (Volume 879)

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1404-1407

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https://doi.org/10.4028/www.scientific.net/MSF.879.1404

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Online since:

November 2016

Authors:

Håkan Nygren*, Per Malmberg, Yang Liu

Keywords:

Bone Cement, Bone Healing, Hydroxyl-Apatite, Magnesium

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