Synthesis of Biotinylated pH-Sensitive Glycopolymer with Different Architectures

Zhong Li Niu; Shu Yu Zhu; Xiao Ting Zhang; Xiao Ze Jiang; Mei Fang Zhu

doi:10.4028/www.scientific.net/MSF.898.2373

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HomeMaterials Science ForumMaterials Science Forum Vol. 898Synthesis of Biotinylated pH-Sensitive...

Synthesis of Biotinylated pH-Sensitive Glycopolymer with Different Architectures

Abstract:

Two pH-sensitive Glycopolymers with the same components but with different construction tailored biotin functionalities were developed for controlled release of bortezomib (BTZ).The initiator brominate biotin and glyco-monomer were synthesized precedently to produce the block-and random-biotinylated poly (2-Gluconamidoethyl methacrylate)-poly (2-Diethylaminoethyl methacrylate) (block/random Biotin-PGAMA-PDEA) via atom transfer radical polymerization (ATRP). The construction and composition of compounds and polymers were characterized by 1H NMR Spectroscopy. The block copolymer self-assembled into micelle according to the pH-response ability of the copolymer while the random one did not under certain conditions.

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Periodical:

Materials Science Forum (Volume 898)

Pages:

2373-2377

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.898.2373

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Online since:

June 2017

Authors:

Zhong Li Niu, Shu Yu Zhu, Xiao Ting Zhang, Xiao Ze Jiang*, Mei Fang Zhu

Keywords:

Amphiphilic Copolymers, Biotinylated, Glycopolymer, pH-Sensitive

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