Paper Titles

Developing a Physically Cross-Linked Hydroxyethyl Cellulose Hydrogel for Wound Dressing Applications
p.3

Exposure-Dependent Antimicrobial Activity and Oxidative Properties of Polymer-Based Graphene Oxide Nanocomposites
p.13

Preparation, Characterization, and Encapsulation Efficiency Test of Simvastatin Microencapsulation Using Polyblend of Poly(Lactic Acid)and Poly(ɛ-Caprolactone)
p.21

Characterization and Efficiency Test of Nifedipine (NIF) Microencapsulation Using Polyblend of Poly(Lactic Acid) and Poly(Ɛ-Caprolactone)
p.26

Synthesis and Characterization of Tin Oxide-MultiWalled Carbon Nanotube Composite Material as Carbon Monoxide Gas Sensor
p.35

Effect of CS₂ Flow Rate on the Formation of Aligned Carbon Microcoils
p.40

Novel Preparation and Characterization of Fe₂O₃/CNT Thin Films for Flammable Gas Sensors
p.47

Experimental Study on a Chemisorption Refrigeration System Prototype Using Expanded Graphite/Activated Carbon/Lithium Chloride-Ammonia Working Pair in a Solution of 25% NH₃
p.52

HomeMaterials Science ForumMaterials Science Forum Vol. 947Exposure-Dependent Antimicrobial Activity and...

Exposure-Dependent Antimicrobial Activity and Oxidative Properties of Polymer-Based Graphene Oxide Nanocomposites

Article Preview

Abstract:

Bacterial proliferation and biofilm formation has emerged as a significant concern in the long-term use of industrial apparatus. This study describes the antimicrobial properties of a novel chitosan-polyethyleneimine-graphene oxide (CS-PEI-GO) nanocomposite against E. coli. The nanocomposite is a stable material with minimal dispersibility in storage water after more than 7 days. The antimicrobial activity is contact-time-dependent, with direct contact (92% bacterial inactivation after 3h exposure) having superior results compared with dynamic contact (~50% inactivation after 3h exposure). In addition, the incorporation of GO also translated to enhanced production of ROS—oxidation of GSH was higher in CS-PEI-GO (31.78%) as compared to CS-PEI alone (5.69%). This may be attributed to previously proposed mechanisms of mechanical membrane damage and reactive oxygen species production that may be more pronounced with prolonged contact. This may be due to the positively charged chitosan and the negatively charged cell membrane facilitating the coating of cells that could allow the oxygen-containing functional groups of GO to induce oxidative stress and lead to cell death.

You might also be interested in these eBooks

Nano Engineering and Materials Technologies III

Info:

Periodical:

Materials Science Forum (Volume 947)

Pages:

13-20

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.947.13

Citation:

Cite this paper

Online since:

March 2019

Authors:

Jem Valerie D. Perez*, Joy Vanessa D. Perez, Raniv D. Rojo, Maria Lourdes P. Dalida, Debora F. Rodrigues

Keywords:

Antimicrobial, Chitosan, Graphene Oxide, Polyethyleneimine, Reactive Oxygen Species

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2019 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] L. Hall-Stoodley, J.W. Costerton and P. Stoodley: Nat Rev Microbiol Vol. 2, No. 2 (2004), pp.95-108.

DOI: 10.1038/nrmicro821

[2] S.E. Coetser and T.E. Cloete: Crit Rev Microbiol Vol. 31 (2005), pp.213-232.

[3] D.M. Yebra, S. Kiil and K. Dam-Johansen: Progress in Organic Coatings Vol. 50, No. 2 (2004), pp.75-104.

DOI: 10.1016/j.porgcoat.2003.06.001

[4] A.R. Varela and C.M. Manaia: Environ Sci Pollut Res Int Vol. 20, No. 6 (2013), pp.3550-69.

[5] S.C. Smith and D.F. Rodrigues: Carbon Vol. 91 (2015), pp.122-143.

[6] I.E. Mejias Carpio, J.D. Mangadlao, H.N. Nguyen, R.C. Advincula and D.F. Rodrigues: Carbon Vol. 77 (2014), pp.289-301.

DOI: 10.1016/j.carbon.2014.05.032

[7] Q. Bao, D. Zhang and P. Qi: J Colloid Interface Sci Vol. 360, No. 2 (2011), pp.463-470.

[8] S. Liu, T.H. Zeng, M. Hofmann, E. Burcombe, J. Wei, R. Jiang, J. Kong and Y. Chen: ACS Nano Vol. 5, No. 9 (2011), pp.6971-6980.

DOI: 10.1021/nn202451x

[9] I.E. Mejias Carpio, C.M. Santos, X. Wei and D.F. Rodrigues: Nanoscale Vol. 4, No. 15 (2012), pp.4746-56.

[10] F. Ahmed and D.F. Rodrigues: J Hazard Mater Vol. 256-257 (2013), pp.33-39.

[11] C.M. Santos, M.C. Tria, R.A. Vergara, F. Ahmed, R.C. Advincula and D.F. Rodrigues: Chem Commun Vol. 47 (2011), pp.8892-8894.

[12] L. Li, L. Fan, M. Sun, H. Qiu, X. Li, H. Duan and C. Luo: Colloids Surf B Biointerfaces Vol. 107 (2013), pp.76-83.

[13] L. Liu, C. Li, C. Bao, Q. Jia, P. Xiao, X. Liu and Q. Zhang: Talanta Vol. 93 (2012), pp.350-357.

[14] Y.L.F. Musico, C.M. Santos, M.L.P. Dalida and D.F. Rodrigues: J. Mater. Chem. A Vol. 1, No. 11 (2013), pp.3789-3796.

[15] F.C. Wu, R.L. Tseng and R.S. Juang: Journal of Environmental Management Vol. 91, No. 4 (2010), pp.798-806.

[16] F. Devlieghere, A. Vermeulen and J. Debevere: Food Microbiology Vol. 21, No. 6 (2004), pp.703-714.

[17] H.N. Lim, N.M. Huang and C.H. Loo: Journal of Non-Crystalline Solids Vol. 358, No. 3 (2012), pp.525-530.

[18] Y. Jiang, J.L. Gong, G.M. Zeng, X.M. Ou, Y.N. Chang, C.H. Deng, J. Zhang, H.Y. Liu and S.Y. Huang: Int J Biol Macromol Vol. 82 (2016), pp.702-710.

[19] S. Deng: Environmental Science and Technology Vol. 39, No. 21 (2005), pp.8490-8496.

[20] B. Qiu, J. Guo, X. Zhang, D. Sun, H. Gu, Q. Wang, H. Wang, X. Wang, X. Zhang, B.L. Weeks, Z. Guo and S. Wei: ACS Appl Mater Interfaces Vol. 6, No. 22 (2014), pp.19816-19824.

DOI: 10.1021/am505170j

[21] J.V.D. Perez, E.T. Nadres, H.N. Nguyen, M.L.P. Dalida and D.F. Rodrigues: RSC Adv. Vol. 7, No. 30 (2017), pp.18480-18490.

DOI: 10.1039/c7ra00750g

[22] S. Kang, M. Herzberg, D.F. Rodrigues and M. Elimelech: Langmuir Vol. 24, No. 13 (2008), pp.6409-6413.

DOI: 10.1021/la800951v