Developing a Physically Cross-Linked Hydroxyethyl Cellulose Hydrogel for Wound Dressing Applications

Abstract:

Physically cross-linked hydroxyethyl cellulose (HEC) hydrogels of different concentrations are synthesized at room temperature, and the hydrogel films are evaluated for its antimicrobial and exudate absorption properties. Results showed that all the hydrogels inherently possess antimicrobial property for all the HEC concentrations tested. The maximum water uptake is determined to be 173.8% for the 13.75% HEC hydrogel. At the same HEC concentration, the hydrogel absorbed the largest amount of exudate. The rate of diffusion in the longitudinal direction is observed to be higher, but the exudate was observed to travel generally farther in the radial direction. The diffusion coefficient model reported by Kipcak, et al. in 2014 was observed to be valid and applicable for the HEC hydrogels. Lastly, scanning electron microscopy showed the microstructure of the fibers and pores of the hydrogels.

• Periodical: Materials Science Forum (Volume 947)
• Pages: 3-12
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.947.3
• Online since: March 2019
• Authors: Jamico Jamlang, Mica Therese Marañon, Girro Jonn Rigor, Terence Tumolva*
• Keywords: Diffusion, Hydrogel, Hydroxyethyl Cellulose, Wound Dressing

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